The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective. This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to sear...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-21
Main Authors: Xu, Yunxiang, Huang, Jiajia, Wang, Fengyi, Liang, Junquan, Chen, Guizhen
Format: Article
Language:English
Subjects:
Acupuncture
Age
Analysis
Bias
Bones
Chinese medicine
Clinical trials
Femur
Fractures
Herbal medicine
Kidneys
Medicine, Chinese
Meta-analysis
Osteoporosis
Quality control
Spine (lumbar)
Statistical analysis
Systematic review
Traditional Chinese medicine
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creator Xu, Yunxiang
Huang, Jiajia
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description Objective. This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P
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This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P&lt;0.00001), BMD of the lumbar spine (SMD = 0.71; 95% CI (0.47, 0.95); P&lt;0.00001) and proximal femur (SMD = 0.94; 95% CI (0.49, 1.38); P&lt;0.00001), TCM symptom integral (SMD = −1.23; 95% CI (−1.43, −1.02); P&lt;0.00001), and VAS scores (SMD = −3.88; 95% CI (−5.29, −2.46); P&lt;0.00001), when compared to using CWM alone and with significant differences. Besides, in respect of adverse effects, it showed no significant statistical difference between the experimental and control groups, RR = 0.99 and 95% CI (0.65, 1.51), P=0.97. Conclusion. Our meta-analysis provides promising evidence to suggest that using the TS (TK) principle combined with CWM for POP is more effective than using CWM alone. Also, both of them are safe and reliable for POP.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/5687421</identifier><identifier>PMID: 33082825</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acupuncture ; Age ; Analysis ; Bias ; Bones ; Chinese medicine ; Clinical trials ; Femur ; Fractures ; Herbal medicine ; Kidneys ; Medicine, Chinese ; Meta-analysis ; Osteoporosis ; Quality control ; Spine (lumbar) ; Statistical analysis ; Systematic review ; Traditional Chinese medicine</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-21</ispartof><rights>Copyright © 2020 Junquan Liang et al.</rights><rights>COPYRIGHT 2020 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2020 Junquan Liang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P&lt;0.00001), BMD of the lumbar spine (SMD = 0.71; 95% CI (0.47, 0.95); P&lt;0.00001) and proximal femur (SMD = 0.94; 95% CI (0.49, 1.38); P&lt;0.00001), TCM symptom integral (SMD = −1.23; 95% CI (−1.43, −1.02); P&lt;0.00001), and VAS scores (SMD = −3.88; 95% CI (−5.29, −2.46); P&lt;0.00001), when compared to using CWM alone and with significant differences. Besides, in respect of adverse effects, it showed no significant statistical difference between the experimental and control groups, RR = 0.99 and 95% CI (0.65, 1.51), P=0.97. Conclusion. Our meta-analysis provides promising evidence to suggest that using the TS (TK) principle combined with CWM for POP is more effective than using CWM alone. 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This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P&lt;0.00001), BMD of the lumbar spine (SMD = 0.71; 95% CI (0.47, 0.95); P&lt;0.00001) and proximal femur (SMD = 0.94; 95% CI (0.49, 1.38); P&lt;0.00001), TCM symptom integral (SMD = −1.23; 95% CI (−1.43, −1.02); P&lt;0.00001), and VAS scores (SMD = −3.88; 95% CI (−5.29, −2.46); P&lt;0.00001), when compared to using CWM alone and with significant differences. Besides, in respect of adverse effects, it showed no significant statistical difference between the experimental and control groups, RR = 0.99 and 95% CI (0.65, 1.51), P=0.97. Conclusion. Our meta-analysis provides promising evidence to suggest that using the TS (TK) principle combined with CWM for POP is more effective than using CWM alone. Also, both of them are safe and reliable for POP.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>33082825</pmid><doi>10.1155/2020/5687421</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-6928-3390</orcidid><orcidid>https://orcid.org/0000-0002-6360-7630</orcidid><oa>free_for_read</oa></addata></record>
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subjects Acupuncture
Age
Analysis
Bias
Bones
Chinese medicine
Clinical trials
Femur
Fractures
Herbal medicine
Kidneys
Medicine, Chinese
Meta-analysis
Osteoporosis
Quality control
Spine (lumbar)
Statistical analysis
Systematic review
Traditional Chinese medicine
title The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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