A comparison of prognoses between surgical resection and radiofrequency ablation therapy for patients with hepatocellular carcinoma and esophagogastric varices

There has been insufficient investigation of the differences in long-term outcomes between surgical resection (SR) and radiofrequency ablation (RFA) among patients with hepatocellular carcinoma (HCC) and esophagogastric varices (EGV). We retrospectively enrolled 251 patients with treatment-naïve HCC...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.17259-17259, Article 17259
Main Authors: Wei, Cheng-Yi, Chau, Gar-Yang, Chen, Ping-Hsien, Liu, Chien-An, Huang, Yi-Hsiang, Huo, Teh-Ia, Hou, Ming-Chih, Lin, Han-Chieh, Su, Yu-Hui, Wu, Jaw-Ching, Su, Chien-Wei
Format: Article
Language:English
Subjects:
631/67/1059
692/4020/4021
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Esophageal and Gastric Varices - surgery
Female
Humanities and Social Sciences
Humans
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Middle Aged
multidisciplinary
Prognosis
Proportional Hazards Models
Radiofrequency Ablation
Retrospective Studies
Science
Science (multidisciplinary)
Survival Rate
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Summary:There has been insufficient investigation of the differences in long-term outcomes between surgical resection (SR) and radiofrequency ablation (RFA) among patients with hepatocellular carcinoma (HCC) and esophagogastric varices (EGV). We retrospectively enrolled 251 patients with treatment-naïve HCC and EGV who underwent SR or RFA as a first-line treatment. Prognostic factors were analyzed using a Cox proportional hazards model. A total of 68 patients underwent SR, and the remaining 183 patients received RFA. Patients who underwent SR were younger, had better liver functional reserves, and had larger tumors. After a median follow-up duration of 45.1 months, 151 patients died. The cumulative 5-year overall survival (OS) rate was significantly higher among patients who underwent SR than those treated with RFA (66.7% vs. 36.8%, p   65 years, multiple tumors, RFA, albumin bilirubin grade > 1, and the occurrence of major peri-procedural morbidity were the independent risk factors that are predictive of poor OS. In conclusion, SR could be recommended as a first-line treatment modality for HCC patients with EGV if the patients are carefully selected and liver function is well preserved.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-74424-y