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Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor
Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET (
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| Published in: | Cancers 2020-09, Vol.12 (9), p.2501 |
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| creator | Goksu, Suleyman Yasin Ozer, Muhammet Kazmi, Syed Mohammad Ali Sanford, Nina Niu Aguilera, Todd A. Ahn, Chul Hsiehchen, David Sanjeevaiah, Aravind Khosama, Leticia Bleeker, Jonathan Atiq, Muslim Beg, Muhammad Shaalan |
| description | Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET ( |
| doi_str_mv | 10.3390/cancers12092501 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7563582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A638189975</galeid><sourcerecordid>A638189975</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-ad3a4cd02e76a623d2265a7c035d0a326cc4ea8c01f6e0ad14a8b85990f84c253</originalsourceid><addsrcrecordid>eNpdkc1L5jAQxsPisop69lrw4qWajzZpLoK8uu6CqAf34CmM0-lrpG-iSSv432-Ksh_OZQaeH898MXYg-LFSlp8gBKSUheRWtlx8YTuSG1lrbZutf-pttp_zEy-hlDDafGPbSnbWSiN22O25z5MPOFWr0QePMFarR0iAE6VFwVz5UN3HOazrm5Bpqm5L10RQpOqa5hQp9BGTD1TdzZuY9tjXAcZM-x95l_36fnG3-lFf3Vz-XJ1d1dhIPdXQK2iw55KMBi1VL6VuwSBXbc9BSY3YEHTIxaCJQy8a6B661lo-dA3KVu2y03ff5_lhQz1SmBKM7jn5DaQ3F8G7_5XgH906vjrTatV2shgcfRik-DJTntzGZ6RxhEBxzk42jZDlXIoX9PAT-hTnFMp6C8WNsNyKv9QaRnI-DLH0xcXUnWnViXJys8x98k5hijknGv6MLLhb3uo-vVX9Bii3lRE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2440719091</pqid></control><display><type>article</type><title>Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central</source><creator>Goksu, Suleyman Yasin ; Ozer, Muhammet ; Kazmi, Syed Mohammad Ali ; Sanford, Nina Niu ; Aguilera, Todd A. ; Ahn, Chul ; Hsiehchen, David ; Sanjeevaiah, Aravind ; Khosama, Leticia ; Bleeker, Jonathan ; Atiq, Muslim ; Beg, Muhammad Shaalan</creator><creatorcontrib>Goksu, Suleyman Yasin ; Ozer, Muhammet ; Kazmi, Syed Mohammad Ali ; Sanford, Nina Niu ; Aguilera, Todd A. ; Ahn, Chul ; Hsiehchen, David ; Sanjeevaiah, Aravind ; Khosama, Leticia ; Bleeker, Jonathan ; Atiq, Muslim ; Beg, Muhammad Shaalan</creatorcontrib><description>Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET (<50 years) and TOPNET (≥50 years) who underwent definitive surgery diagnosed between 2004 and 2016 using the National Cancer Database. We evaluated overall survival (OS) using the Kaplan–Meier and Cox regression methods before and after propensity score matching. A publicly available genomic dataset was used to compare mutation frequencies among the two groups. Results: A total of 6259 patients with PNET were included, of which 27% were YOPNET. Patients with YOPNET were more likely to be Black, Hispanic, female, and have private insurance versus patients with TOPNET (all p < 0.001). Patients with YOPNET had a lower comorbidity score, but higher stage and tumor size (all p < 0.001). YOPNET was associated with a greater improved OS than TOPNET before and after propensity score matching (p < 0.001). On multivariable analysis, this survival difference persisted for YOPNET as an independent prognostic factor (unmatched p = 0.008; matched p = 0.01). For genomic analysis, patients with YOPNET had a lower rate of multiple endocrine neoplasia type-1 (MEN-1) mutation than patients with TOPNET (26% vs. 56%, p < 0.001). Conclusions: YOPNET represents a disease with distinct clinical features. Patients with YOPNET who underwent definitive surgery had better OS than patients with TOPNET despite having higher stage and tumor size. YOPNET also had lower rate of MEN-1 mutation.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers12092501</identifier><identifier>PMID: 32899271</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Comorbidity ; Genomic analysis ; Health aspects ; Medical prognosis ; Multiple endocrine neoplasia ; Mutation ; Neuroendocrine tumors ; Pancreas ; Patients ; Socioeconomic factors ; Surgery ; Survival</subject><ispartof>Cancers, 2020-09, Vol.12 (9), p.2501</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-ad3a4cd02e76a623d2265a7c035d0a326cc4ea8c01f6e0ad14a8b85990f84c253</citedby><cites>FETCH-LOGICAL-c426t-ad3a4cd02e76a623d2265a7c035d0a326cc4ea8c01f6e0ad14a8b85990f84c253</cites><orcidid>0000-0001-9453-342X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2440719091/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2440719091?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Goksu, Suleyman Yasin</creatorcontrib><creatorcontrib>Ozer, Muhammet</creatorcontrib><creatorcontrib>Kazmi, Syed Mohammad Ali</creatorcontrib><creatorcontrib>Sanford, Nina Niu</creatorcontrib><creatorcontrib>Aguilera, Todd A.</creatorcontrib><creatorcontrib>Ahn, Chul</creatorcontrib><creatorcontrib>Hsiehchen, David</creatorcontrib><creatorcontrib>Sanjeevaiah, Aravind</creatorcontrib><creatorcontrib>Khosama, Leticia</creatorcontrib><creatorcontrib>Bleeker, Jonathan</creatorcontrib><creatorcontrib>Atiq, Muslim</creatorcontrib><creatorcontrib>Beg, Muhammad Shaalan</creatorcontrib><title>Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor</title><title>Cancers</title><description>Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET (<50 years) and TOPNET (≥50 years) who underwent definitive surgery diagnosed between 2004 and 2016 using the National Cancer Database. We evaluated overall survival (OS) using the Kaplan–Meier and Cox regression methods before and after propensity score matching. A publicly available genomic dataset was used to compare mutation frequencies among the two groups. Results: A total of 6259 patients with PNET were included, of which 27% were YOPNET. Patients with YOPNET were more likely to be Black, Hispanic, female, and have private insurance versus patients with TOPNET (all p < 0.001). Patients with YOPNET had a lower comorbidity score, but higher stage and tumor size (all p < 0.001). YOPNET was associated with a greater improved OS than TOPNET before and after propensity score matching (p < 0.001). On multivariable analysis, this survival difference persisted for YOPNET as an independent prognostic factor (unmatched p = 0.008; matched p = 0.01). For genomic analysis, patients with YOPNET had a lower rate of multiple endocrine neoplasia type-1 (MEN-1) mutation than patients with TOPNET (26% vs. 56%, p < 0.001). Conclusions: YOPNET represents a disease with distinct clinical features. Patients with YOPNET who underwent definitive surgery had better OS than patients with TOPNET despite having higher stage and tumor size. YOPNET also had lower rate of MEN-1 mutation.</description><subject>Age</subject><subject>Comorbidity</subject><subject>Genomic analysis</subject><subject>Health aspects</subject><subject>Medical prognosis</subject><subject>Multiple endocrine neoplasia</subject><subject>Mutation</subject><subject>Neuroendocrine tumors</subject><subject>Pancreas</subject><subject>Patients</subject><subject>Socioeconomic factors</subject><subject>Surgery</subject><subject>Survival</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc1L5jAQxsPisop69lrw4qWajzZpLoK8uu6CqAf34CmM0-lrpG-iSSv432-Ksh_OZQaeH898MXYg-LFSlp8gBKSUheRWtlx8YTuSG1lrbZutf-pttp_zEy-hlDDafGPbSnbWSiN22O25z5MPOFWr0QePMFarR0iAE6VFwVz5UN3HOazrm5Bpqm5L10RQpOqa5hQp9BGTD1TdzZuY9tjXAcZM-x95l_36fnG3-lFf3Vz-XJ1d1dhIPdXQK2iw55KMBi1VL6VuwSBXbc9BSY3YEHTIxaCJQy8a6B661lo-dA3KVu2y03ff5_lhQz1SmBKM7jn5DaQ3F8G7_5XgH906vjrTatV2shgcfRik-DJTntzGZ6RxhEBxzk42jZDlXIoX9PAT-hTnFMp6C8WNsNyKv9QaRnI-DLH0xcXUnWnViXJys8x98k5hijknGv6MLLhb3uo-vVX9Bii3lRE</recordid><startdate>20200903</startdate><enddate>20200903</enddate><creator>Goksu, Suleyman Yasin</creator><creator>Ozer, Muhammet</creator><creator>Kazmi, Syed Mohammad Ali</creator><creator>Sanford, Nina Niu</creator><creator>Aguilera, Todd A.</creator><creator>Ahn, Chul</creator><creator>Hsiehchen, David</creator><creator>Sanjeevaiah, Aravind</creator><creator>Khosama, Leticia</creator><creator>Bleeker, Jonathan</creator><creator>Atiq, Muslim</creator><creator>Beg, Muhammad Shaalan</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9453-342X</orcidid></search><sort><creationdate>20200903</creationdate><title>Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor</title><author>Goksu, Suleyman Yasin ; Ozer, Muhammet ; Kazmi, Syed Mohammad Ali ; Sanford, Nina Niu ; Aguilera, Todd A. ; Ahn, Chul ; Hsiehchen, David ; Sanjeevaiah, Aravind ; Khosama, Leticia ; Bleeker, Jonathan ; Atiq, Muslim ; Beg, Muhammad Shaalan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-ad3a4cd02e76a623d2265a7c035d0a326cc4ea8c01f6e0ad14a8b85990f84c253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Comorbidity</topic><topic>Genomic analysis</topic><topic>Health aspects</topic><topic>Medical prognosis</topic><topic>Multiple endocrine neoplasia</topic><topic>Mutation</topic><topic>Neuroendocrine tumors</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Socioeconomic factors</topic><topic>Surgery</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goksu, Suleyman Yasin</creatorcontrib><creatorcontrib>Ozer, Muhammet</creatorcontrib><creatorcontrib>Kazmi, Syed Mohammad Ali</creatorcontrib><creatorcontrib>Sanford, Nina Niu</creatorcontrib><creatorcontrib>Aguilera, Todd A.</creatorcontrib><creatorcontrib>Ahn, Chul</creatorcontrib><creatorcontrib>Hsiehchen, David</creatorcontrib><creatorcontrib>Sanjeevaiah, Aravind</creatorcontrib><creatorcontrib>Khosama, Leticia</creatorcontrib><creatorcontrib>Bleeker, Jonathan</creatorcontrib><creatorcontrib>Atiq, Muslim</creatorcontrib><creatorcontrib>Beg, Muhammad Shaalan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest_Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goksu, Suleyman Yasin</au><au>Ozer, Muhammet</au><au>Kazmi, Syed Mohammad Ali</au><au>Sanford, Nina Niu</au><au>Aguilera, Todd A.</au><au>Ahn, Chul</au><au>Hsiehchen, David</au><au>Sanjeevaiah, Aravind</au><au>Khosama, Leticia</au><au>Bleeker, Jonathan</au><au>Atiq, Muslim</au><au>Beg, Muhammad Shaalan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor</atitle><jtitle>Cancers</jtitle><date>2020-09-03</date><risdate>2020</risdate><volume>12</volume><issue>9</issue><spage>2501</spage><pages>2501-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET (<50 years) and TOPNET (≥50 years) who underwent definitive surgery diagnosed between 2004 and 2016 using the National Cancer Database. We evaluated overall survival (OS) using the Kaplan–Meier and Cox regression methods before and after propensity score matching. A publicly available genomic dataset was used to compare mutation frequencies among the two groups. Results: A total of 6259 patients with PNET were included, of which 27% were YOPNET. Patients with YOPNET were more likely to be Black, Hispanic, female, and have private insurance versus patients with TOPNET (all p < 0.001). Patients with YOPNET had a lower comorbidity score, but higher stage and tumor size (all p < 0.001). YOPNET was associated with a greater improved OS than TOPNET before and after propensity score matching (p < 0.001). On multivariable analysis, this survival difference persisted for YOPNET as an independent prognostic factor (unmatched p = 0.008; matched p = 0.01). For genomic analysis, patients with YOPNET had a lower rate of multiple endocrine neoplasia type-1 (MEN-1) mutation than patients with TOPNET (26% vs. 56%, p < 0.001). Conclusions: YOPNET represents a disease with distinct clinical features. Patients with YOPNET who underwent definitive surgery had better OS than patients with TOPNET despite having higher stage and tumor size. YOPNET also had lower rate of MEN-1 mutation.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32899271</pmid><doi>10.3390/cancers12092501</doi><orcidid>https://orcid.org/0000-0001-9453-342X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Comorbidity Genomic analysis Health aspects Medical prognosis Multiple endocrine neoplasia Mutation Neuroendocrine tumors Pancreas Patients Socioeconomic factors Surgery Survival |
| title | Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor |
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