Association between Family Histories of Thyroid Cancer and Thyroid Cancer Incidence: A Cross-Sectional Study Using the Korean Genome and Epidemiology Study Data

This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group....

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Bibliographic Details
Published in:Genes 2020-09, Vol.11 (9), p.1039
Main Authors: Byun, Soo-Hwan, Min, Chanyang, Choi, Hyo-Geun, Hong, Seok-Jin
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Alcohol Drinking - physiopathology
Cross-Sectional Studies
Demographic aspects
Distribution
Epidemiology
Family medical history
Female
Genetic aspects
Genome, Human
Genomes
Humans
Incidence
Kinases
Male
Middle Aged
Mutation
Obesity - physiopathology
Republic of Korea - epidemiology
Risk Factors
Siblings
Smoking - physiopathology
Thyroid cancer
Thyroid Neoplasms - epidemiology
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Summary:This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group. Trained interviewers questioned the participants to obtain their thyroid cancer history and age at onset. The participants were examined according to their age, sex, monthly household income, obesity, smoking, alcohol consumption, and past medical history. The adjusted odds ratios (95% confidence intervals) for the family histories of fathers, mothers, and siblings were 6.59 (2.05-21.21), 4.76 (2.59-8.74), and 9.53 (6.92-13.11), respectively, and were significant. The results for the subgroup analyses according to sex were consistent. The rate of family histories of thyroid cancer for fathers and siblings were not different according to the thyroid cancer onset, while that of mothers were higher in participants with a younger age at onset (
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11091039