Snail-1 Overexpression Correlates with Metastatic Phenotype in BRAFV600E Positive Papillary Thyroid Carcinoma

The ability of cancer to metastasize is regulated by various signaling pathways, including transforming growth factor β (TGFβ), also implicated in the upregulation of Snail-1 transcription factor in malignant neoplasms. B-type Raf kinase gene (BRAF)V600E, the most common driving mutation in papillar...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-08, Vol.9 (9), p.2701
Main Authors: Wieczorek-Szukala, Katarzyna, Kopczynski, Janusz, Kowalska, Aldona, Lewinski, Andrzej
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Clinical medicine
Gene expression
Genotype & phenotype
Growth factors
Kinases
Lymphatic system
Medical prognosis
Metastasis
Mutation
Physiology
Proteins
Thyroid cancer
Transcription factors
Tumors
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Summary:The ability of cancer to metastasize is regulated by various signaling pathways, including transforming growth factor β (TGFβ), also implicated in the upregulation of Snail-1 transcription factor in malignant neoplasms. B-type Raf kinase gene (BRAF)V600E, the most common driving mutation in papillary thyroid carcinoma (PTC), induces epithelial to mesenchymal transition (EMT) in thyroid cancer cells through changes in the Snail-1 level, increasing cell migration and invasion. However, little is known about the mechanism of Snail-1 and BRAFV600E relations in humans. Our study included 61 PTC patients with evaluated BRAFV600E mutation status. A total of 18 of those patients had lymph node metastases—of whom 10 were BRAFV600E positive, and 8 negative. Our findings indicate that the expression of Snail-1, but not TGFβ1, correlates with the metastatic phenotype in PTC. This is the first piece of evidence that the upregulation of Snail-1 corresponds with the presence of BRAFV600E mutation and increased expression of Snail-1 in metastatic PTC samples is dependent on BRAFV600E mutation status.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9092701