Interstitial lung disease and microscopic polyangiitis in chilean patients

To describe the clinical and serological patients characteristics with Microscopic Polyangiitis (MPA) and Interstitial lung disease (ILD). Of all the patients with AAV diagnosed between 2007-2017 at the Hospital Clinico Universidad de Chile, those with MPA and ILD were selected and studied retrospec...

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Published in:Sarcoidosis, vasculitis, and diffuse lung diseases vasculitis, and diffuse lung diseases, 2020-01, Vol.37 (1), p.37-42
Main Authors: Wurmann, Pamela, Sabugo, Francisca, Elgueta, Fabian, Mac-Namara, Macarena, Vergara, Karen, Vargas, Daniela, Molina, Maria Luisa, Díaz, Juan Carlos, Gatica, Hector, Goecke, Annelise
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies, Antineutrophil Cytoplasmic - blood
Biomarkers - blood
Chile
Female
Humans
Lung Diseases, Interstitial - blood
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - immunology
Male
Microscopic Polyangiitis - blood
Microscopic Polyangiitis - diagnosis
Microscopic Polyangiitis - immunology
Middle Aged
Original : Clinical Research
Peroxidase - immunology
Predictive Value of Tests
Prognosis
Retrospective Studies
Serologic Tests
Tomography, X-Ray Computed
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Summary:To describe the clinical and serological patients characteristics with Microscopic Polyangiitis (MPA) and Interstitial lung disease (ILD). Of all the patients with AAV diagnosed between 2007-2017 at the Hospital Clinico Universidad de Chile, those with MPA and ILD were selected and studied retrospectively. All patients were Hispanic; median age at diagnosis 65 years (32-84). 59% were female. All were positive for p-ANCA, 16 patients for MPO. Most common manifestations were constitutional symptoms, weight loss and fever. CT-Scans patterns were Usual Interstitial Pneumonia (UIP) in 10 patients, Nonspecific Interstitial Pneumonia (NSIP) in 6 and fibrosis not UIP or NSIP pattern in 1. In 6 cases, ILD was diagnosed 0.5-14 years before MPA and concomitantly in 11. Although infrequent, Microscopic Polyangiitis should be suspected in patients with ILD particularly if extra-pulmonary manifestations that rise the possibility of a systemic illness are present, regardless of the time elapsed between the latter and the diagnosis of this type of lung involvement. .
ISSN:1124-0490
2532-179X
DOI:10.36141/svdld.v37i1.7980