TSLP drives acute Th2 differentiation in lungs

Our study showed TSLP promotes rapid primary Th2 driven airway inflammation, which provides a novel mechanism in development of inflammation in tissue; and more importantly, a potential explanation for efficacy of anti-TSLP therapy in moderate-to-severe asthmatic patients.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2020-04, Vol.146 (6), p.1406-1418.e7
Main Authors: Lai, Jen-Feng, Thompson, Lucas J., Ziegler, Steven F.
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:Our study showed TSLP promotes rapid primary Th2 driven airway inflammation, which provides a novel mechanism in development of inflammation in tissue; and more importantly, a potential explanation for efficacy of anti-TSLP therapy in moderate-to-severe asthmatic patients.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2020.03.032