A Pilot Study to Assess Transfusion Transmission of Hepatitis C Virus

Alexandria University blood bank adopted double screening tests: a fully automated chemiluminescence immunoassay followed by nucleic acid testing. The aim of the study was to assess the efficiency of dual check of HCV in preventing transfusion related infection among patients admitted to PICU. A pro...

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Bibliographic Details
Published in:Indian journal of hematology & blood transfusion 2020-10, Vol.36 (4), p.745-748
Main Authors: El-Nawawy, Ahmed, Arafa, Shams Abdel-Fattah, Badeib, Adham Ahmed, Antonios, Manal A.-M.
Format: Article
Language:English
Subjects:
Blood Transfusion Medicine
Blood transfusions
Disease control
Disease transmission
Hematology
Hepatitis
Hepatitis C
Human Genetics
Medicine
Medicine & Public Health
Oncology
Pediatrics
Short Communication
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Summary:Alexandria University blood bank adopted double screening tests: a fully automated chemiluminescence immunoassay followed by nucleic acid testing. The aim of the study was to assess the efficiency of dual check of HCV in preventing transfusion related infection among patients admitted to PICU. A prospective cohort study was carried on patients admitted to PICU during 6 months. The included patients performed HCV RNA detection on admission by conventional reverse transcriptase polymerase chain reaction (RT-PCR) technique. Only negative cases were recruited, then patients receiving blood or its product were checked after 4 weeks from discharge by RT-PCR for HCV RNA. A total of 33 patients received 108 transfusions: 9 patients of them deceased during PICU stay and the remaining 24 patients were all found to be negative for HCV. The dual screening of HCV should be implemented in all blood banks of Egypt especially for critically ill pediatric patients.
ISSN:0971-4502
0974-0449
0974-0449
0971-4502
DOI:10.1007/s12288-020-01265-0