Update on cerebrovascular manifestations of COVID-19

The novel member of coronaviruses family, severe acute respiratory coronavirus-2 (SARS-CoV-2), with high structural homology to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS) has spread rapidly with about 20 million cases infection and over 700,000 deaths. SARS-CoV-2 has be...

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Bibliographic Details
Published in:Neurological sciences 2020-12, Vol.41 (12), p.3423-3435
Main Authors: Naeimi, Reza, Ghasemi–Kasman, Maryam
Format: Article
Language:English
Subjects:
Betacoronavirus
Cerebrovascular Disorders - virology
Coronaviridae
Coronavirus Infections - complications
Coronaviruses
COVID-19
Homology
Humans
Infections
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Pandemics
Pneumonia, Viral - complications
Psychiatry
Respiratory diseases
Respiratory failure
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:The novel member of coronaviruses family, severe acute respiratory coronavirus-2 (SARS-CoV-2), with high structural homology to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS) has spread rapidly with about 20 million cases infection and over 700,000 deaths. SARS-CoV-2 has been emerged as a worldwide disaster due to non-specific few respiratory and gastrointestinal manifestations at the onset of disease as well as long incubation period. Surprisingly, not only respiratory failure but also the underlying coagulation disorder and neurovascular involvement worsen the clinical outcome of infected patients. In this review article, we describe the probable mechanisms of SARS-CoV-2 infection and stroke occurrence. We will also discuss the cerebrovascular events following SARS-CoV-2 infection, the recommended therapies, and future prospects to better manage these patients in coronavirus disease 2019 (COVID-19) outbreak.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-020-04837-0