Physical stimulations and their osteogenesis-inducing mechanisms

Physical stimulations such as magnetic, electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways, modulating ion channels, regulating bonerelated gene expressions, etc. In this paper, bioeffects of physical stimu...

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Bibliographic Details
Published in:International journal of bioprinting 2018-01, Vol.4 (2), p.138-138
Main Authors: Shuai, Cijun, Yang, Wenjing, Peng, Shuping, Gao, Chengde, Guo, Wang, Lai, Yuxiao, Feng, Pei
Format: Article
Language:English
Subjects:
Biomedical materials
Bone growth
Bone healing
Calcium (extracellular)
Calcium (intracellular)
Calcium ions
Cell membranes
Growth factors
Hall effect
Ion channels
Ion migration
Magnetic fields
Mechanical stimuli
Membrane permeability
Osteogenesis
Piezoelectricity
Repair
Signal processing
Stimulation
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Summary:Physical stimulations such as magnetic, electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways, modulating ion channels, regulating bonerelated gene expressions, etc. In this paper, bioeffects of physical stimulations on cell activity, tissue growth and bone healing were systematically summarized, which especially focused on their osteogenesis-inducing mechanisms. Detailedly, magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions, especially accelerating the extracellular calcium ions to pass through cell membrane. Electric stimulation could induce inverse piezoelectric effect which generated electric signals, accordingly up-regulating intracellular calcium levels and growth factor synthesis. And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals, thus activating various signaling pathways on cell membrane and inducing a series of gene expressions. Besides, bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed. The equipments of physical stimulation system were described. The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair.
ISSN:2424-7723
2424-8002
DOI:10.18063/ijb.v4i2.138