Solar Ultraviolet Radiation and Vitamin D Deficiency on Epstein-Barr Virus Reactivation: Observational and Genetic Evidence From a Nasopharyngeal Carcinoma-Endemic Population

Abstract Background We investigated the relationship of Epstein-Barr virus viral capsid antigen (EBV VCA-IgA) serostatus with ambient and personal ultraviolet radiation (UVR) and vitamin D exposure. Methods Using data from a multicenter case-control study, we included 1026 controls subjects in 2014–...

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Published in:Open forum infectious diseases 2020-10, Vol.7 (10), p.ofaa426
Main Authors: Mai, Zhi-Ming, Lin, Jia-Huang, Ngan, Roger Kai-Cheong, Kwong, Dora Lai-Wan, Ng, Wai-Tong, Ng, Alice Wan-Ying, Ip, Kai-Ming, Chan, Yap-Hang, Lee, Anne Wing-Mui, Ho, Sai-Yin, Lung, Maria Li, Lam, Tai-Hing
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Language:English
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Summary:Abstract Background We investigated the relationship of Epstein-Barr virus viral capsid antigen (EBV VCA-IgA) serostatus with ambient and personal ultraviolet radiation (UVR) and vitamin D exposure. Methods Using data from a multicenter case-control study, we included 1026 controls subjects in 2014–2017 in Hong Kong, China. Odds ratios (ORs) and 95% confidence intervals (CIs) of the association between UVR exposure and EBV VCA-IgA (seropositivity vs seronegativity) were calculated using unconditional logistic regression models adjusted for potential confounders. Results We observed a large increase in seropositivity of EBV VCA-IgA in association with duration of sunlight exposures at both 10 years before recruitment and age 19–30 years (adjusted OR = 3.59, 95% CI = 1.46–8.77; and adjusted OR = 2.44, 95% CI = 1.04–5.73 for ≥8 vs
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa426