The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development

Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal research reviews 2020-11, Vol.40 (6), p.2089-2113
Main Authors: Farhan, Mohd, Silva, Marta, Li, Shuai, Yan, Fengxia, Fang, Jiankang, Peng, Tangming, Hu, Jim, Tsao, Ming‐Sound, Little, Peter, Zheng, Wenhua
Format: Article
Language:English
Subjects:
Autophagy
Cancer
FOXO proteins
Metastasis
Mini Review
Mini Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of cancer growth and metastasis. Recent evidence suggests that FOXO proteins are also involved in autophagy regulation. The relationship among FOXOs, autophagy, and cancer has been drawing attention of many who work in the field. This study summarizes the role of FOXO proteins and autophagy in cancer growth and metastasis and analyzes their potential roles in cancer disease management.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21695