Chloroplast genome transformation of medicinal plant Artemisia annua

Artemisia annua produces lifesaving antimalarial drug artemisinin. The biosynthetic pathway of artemisinin is intercalated with chloroplasts of A. annua. Therefore, it will be imperative to optimize its chloroplast transformation for increasing the yield of artemisinin, which has not been achieved t...

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Bibliographic Details
Published in:Plant biotechnology journal 2020-11, Vol.18 (11), p.2155-2157
Main Authors: Kaushal, Charli, Abdin, Malik Zainul, Kumar, Shashi
Format: Article
Language:English
Subjects:
3' Untranslated regions
Amplification
Antibiotics
Artemisinin
artemisinin antimalaria drug
Binding sites
Bombardment
Brief Communication
Brief Communications
Chlorophyll
chloroplast transformation
Chloroplasts
Deoxyribonucleic acid
DNA
Explants
Filter paper
Fluorescence
Genes
Genetic transformation
Genomes
Herbal medicine
homologous recombination
Leaves
Localization
Luminous intensity
Medicinal plants
Photomicrographs
plant genetic engineering
Polymerase chain reaction
Primers
Primers (coatings)
Primordia
Proteins
Seeds
Spectinomycin
Transformations
Wavelengths
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Summary:Artemisia annua produces lifesaving antimalarial drug artemisinin. The biosynthetic pathway of artemisinin is intercalated with chloroplasts of A. annua. Therefore, it will be imperative to optimize its chloroplast transformation for increasing the yield of artemisinin, which has not been achieved to desired levels via nuclear genome transformation (Ikram and Simonsen, 2017). The low yield has limited its current global demand for the artemisinin based combination therapies (ACTs).
ISSN:1467-7644
1467-7652
DOI:10.1111/pbi.13379