Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction

The participation of extracellular vesicles in many cellular processes, including reproduction, is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles are mostly applied as markers, increasing evidence points to their role in extracellular vesicle biogenesis,...

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Published in:International journal of molecular sciences 2020-10, Vol.21 (20), p.7568
Main Authors: Jankovičová, Jana, Sečová, Petra, Michalková, Katarína, Antalíková, Jana
Format: Article
Language:English
Subjects:
Animals
Biosynthesis
Cell adhesion & migration
Embryos
Extracellular vesicles
Extracellular Vesicles - metabolism
Fertilization
Gene expression
Germ Cells - cytology
Germ Cells - metabolism
Humans
Kinases
Lipids
Mammals
Markers
Mitochondrial DNA
Morphology
Pelodiscus sinensis
Plasma
Proteins
Reproduction
Reproductive system
Review
Signal transduction
Somatic cells
Tetraspanins - genetics
Tetraspanins - metabolism
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Summary:The participation of extracellular vesicles in many cellular processes, including reproduction, is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles are mostly applied as markers, increasing evidence points to their role in extracellular vesicle biogenesis, cargo selection, cell targeting, and cell uptake under both physiological and pathological conditions. In this review, we bring other insight into the involvement of tetraspanin proteins in extracellular vesicle physiology in mammalian reproduction. We provide knowledge regarding the involvement of extracellular vesicle tetraspanins in these processes in somatic cells. Furthermore, we discuss the future direction towards an understanding of their functions in the tissues and fluids of the mammalian reproductive system in gamete maturation, fertilization, and embryo development; their involvement in mutual cell contact and communication in their complexity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21207568