Development of a novel immune-related genes prognostic signature for osteosarcoma

Immune-related genes (IRGs) are responsible for osteosarcoma (OS) initiation and development. We aimed to develop an optimal IRGs-based signature to assess of OS prognosis. Sample gene expression profiles and clinical information were downloaded from the Therapeutically Applicable Research to Genera...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.18402, Article 18402
Main Authors: Wu, Zuo-long, Deng, Ya-jun, Zhang, Guang-zhi, Ren, En-hui, Yuan, Wen-hua, Xie, Qi-qi
Format: Article
Language:English
Subjects:
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Biomarkers, Tumor - genetics
Bone cancer
Cohort Studies
Correlation analysis
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genotypes
Humanities and Social Sciences
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Metastases
multidisciplinary
Osteosarcoma
Osteosarcoma - genetics
Osteosarcoma - immunology
Osteosarcoma - pathology
Prognosis
Regression analysis
Risk groups
Sarcoma
Science
Science (multidisciplinary)
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Summary:Immune-related genes (IRGs) are responsible for osteosarcoma (OS) initiation and development. We aimed to develop an optimal IRGs-based signature to assess of OS prognosis. Sample gene expression profiles and clinical information were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Genotype-Tissue Expression (GTEx) databases. IRGs were obtained from the ImmPort database. R software was used to screen differentially expressed IRGs (DEIRGs) and functional correlation analysis. DEIRGs were analyzed by univariate Cox regression and iterative LASSO Cox regression analysis to develop an optimal prognostic signature, and the signature was further verified by independent cohort (GSE39055) and clinical correlation analysis. The analyses yielded 604 DEIRGs and 10 hub IRGs. A prognostic signature consisting of 13 IRGs was constructed, which strikingly correlated with OS overall survival and distant metastasis (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-75573-w