Anti obesity prospective of Dalbergia latifolia (Roxb.) hydroalcoholic bark extract in high fat diet induced obese rats

Obesity is an alarming sign and considered as a threat word wide. Since it not only hurt the human body but plays as a basis for other serious diseases like cardiovascular and many more. The 50% hydro-ethanolic extract of Dalbergia latifolia bark ( D. latifolia ) (DLBE; %yield = 16.34) and methanoli...

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Bibliographic Details
Published in:3 Biotech 2020-11, Vol.10 (11), p.493-493, Article 493
Main Authors: Khalid, Mohammad, Shoaib, Ambreen, Akhtar, Juber, Alqarni, Mohammed H., Badruddeen, Siddiqui, Hefazat H., Foudah, Ahmed I.
Format: Article
Language:English
Subjects:
Acute toxicity
Agriculture
Alanine
Alanine transaminase
Aspartate aminotransferase
Bark
Bioinformatics
Biomaterials
Biotechnology
Body weight
Cancer Research
Chemistry
Chemistry and Materials Science
Cholesterol
Creatinine
Dalbergia latifolia
Density
Diet
Food intake
High density lipoprotein
High fat diet
Kidneys
Lipoproteins
Lipoproteins (very low density)
Liver
Low density lipoprotein
Morbidity
Obesity
Original
Original Article
Plant extracts
Stem Cells
Thin layer chromatography
Toxicity
Transaminase
Triglycerides
Urea
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Summary:Obesity is an alarming sign and considered as a threat word wide. Since it not only hurt the human body but plays as a basis for other serious diseases like cardiovascular and many more. The 50% hydro-ethanolic extract of Dalbergia latifolia bark ( D. latifolia ) (DLBE; %yield = 16.34) and methanolic extract (4.32%) of D. latifolia were made. The DLBE was used for the acute oral toxicity and anti-obesity activity in the rodent. However, methanolic extract was used for characterization by high-performance thin layer chromatography (HPTLC) method. During acute toxicity study, it was shown that certainly there was no mortality or morbidity observed up to the maximum dose of 2000 mg/kg after administration of DLBE. The ultimate body weight, food intake, liver weight, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides (TG), aspartate aminotransferase (AST), alanine transaminase (ALT), serum creatinine and blood urea nitrogen (BUN) of rats treated with DLBE at a dose of 200 and 400 mg/kg respectively was considerably diminished to p  
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-02491-z