Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Objective The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin...

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Published in:Journal of clinical laboratory analysis 2020-10, Vol.34 (10), p.e23618-n/a
Main Authors: Cheng, Linlin, Li, Haolong, Li, Liubing, Liu, Chenxi, Yan, Songxin, Chen, Haizhen, Li, Yongzhe
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Anemia
Betacoronavirus
Comorbidity
Coronaviridae
Coronavirus Infections - blood
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - mortality
Coronaviruses
COVID-19
Cytokine storm
Cytokines
Diabetes mellitus
diagnosis
Disease transmission
Female
Ferritin
Ferritins - blood
Histiocytosis
Humans
Ischemia
Laboratories
Lymphocytosis
Male
Mechanical ventilation
Meta-analysis
Middle Aged
Mortality
Pandemics
Patients
Pneumonia, Viral - blood
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - mortality
Prognosis
Review
SARS-CoV-2
severity
Ventilators
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Summary:Objective The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19. Methods Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation. Results A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P 
ISSN:0887-8013
1098-2825
1098-2825
DOI:10.1002/jcla.23618