Role of gut microbiota via the gut-liver-brain axis in digestive diseases

The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the ne...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2020-10, Vol.26 (40), p.6141-6162
Main Authors: Ding, Jian-Hong, Jin, Zhe, Yang, Xiao-Xu, Lou, Jun, Shan, Wei-Xi, Hu, Yan-Xia, Du, Qian, Liao, Qiu-Shi, Xie, Rui, Xu, Jing-Yu
Format: Article
Language:English
Subjects:
Brain
Enteric Nervous System
Gastrointestinal Microbiome
Humans
Irritable Bowel Syndrome
Liver
Review
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Summary:The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut- liver-brain axis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v26.i40.6141