Label-Free Plasmonic Detection of Untethered Nanometer-Sized Brownian Particles

Optical detection of individual nanometer-sized analytes, virus particles, and protein molecules holds great promise for understanding and control of biological samples and healthcare applications. As fluorescent labels impose restrictions on detection bandwidth and require lengthy and invasive proc...

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Bibliographic Details
Published in:ACS nano 2020-10, Vol.14 (10), p.14212-14218
Main Authors: Baaske, Martin Dieter, Neu, Peter Sebastian, Orrit, Michel
Format: Article
Language:English
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Summary:Optical detection of individual nanometer-sized analytes, virus particles, and protein molecules holds great promise for understanding and control of biological samples and healthcare applications. As fluorescent labels impose restrictions on detection bandwidth and require lengthy and invasive processes, label-free optical techniques are highly desirable. Here, we introduce an optical technique capable of transforming gold nanorods commonly used as photostable labels into highly localized high-speed probes. Our method detects single untethered 5 nm diameter gold particles as they traverse subattoliter volumes in Brownian motion with a time resolution below microseconds.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.0c07335