Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial

Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investi...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.18769, Article 18769
Main Authors: Gong, Yan, Luo, Shan, Fan, Ping, Jin, Song, Zhu, Huili, Deng, Tang, Quan, Yi, Huang, Wei
Format: Article
Language:English
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Apoptosis
China
Clinical trials
Embryo transfer
Embryos
Female
Granulosa cells
Growth Hormone - pharmacology
Growth Hormone - therapeutic use
Growth hormones
Humanities and Social Sciences
Humans
Implantation
In vitro fertilization
Membrane potential
Mitochondria
multidisciplinary
Oocytes
Oocytes - drug effects
Ovaries
Oxidants
Oxidative stress
Oxidative Stress - drug effects
Oxidizing agents
Patients
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - physiopathology
Prospective Studies
Science
Science (multidisciplinary)
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Summary:Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-75107-4