Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human

Caffeine occurs naturally in various foods, such as coffee, tea, and cocoa, and it has been used safely as a mild stimulant for a long time. However, excessive caffeine consumption (1~1.5 g/day) can cause caffeine poisoning (caffeinism), which includes symptoms such as anxiety, agitation, insomnia,...

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Bibliographic Details
Published in:Nutrients 2020-10, Vol.12 (10), p.3080
Main Authors: Jee, Hye Jin, Lee, Sang Goo, Bormate, Katrina Joy, Jung, Yi-Sook
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Alzheimer's disease
Caffeine
Caffeine - administration & dosage
Caffeine - adverse effects
Caffeine - poisoning
Caffeine - therapeutic use
Caffeinism
Coffee
Dose-Response Relationship, Drug
Female
Gastrointestinal diseases
Gender
Gender differences
Humans
Insomnia
Male
Mental disorders
Mental Disorders - etiology
Mental Disorders - prevention & control
Middle Aged
Mortality
Nervous System Diseases - etiology
Nervous System Diseases - prevention & control
Neurological diseases
Precision medicine
Review
Risk analysis
Risk Assessment
Risk Factors
Sex Characteristics
Sex differences
Signs and symptoms
Sleep disorders
Tea
Womens health
Young Adult
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Summary:Caffeine occurs naturally in various foods, such as coffee, tea, and cocoa, and it has been used safely as a mild stimulant for a long time. However, excessive caffeine consumption (1~1.5 g/day) can cause caffeine poisoning (caffeinism), which includes symptoms such as anxiety, agitation, insomnia, and gastrointestinal disorders. Recently, there has been increasing interest in the effect of caffeine consumption as a protective factor or risk factor for neurological and psychiatric disorders. Currently, the importance of personalized medicine is being emphasized, and research on sex/gender differences needs to be conducted. Our review focuses on the effect of caffeine consumption on several neurological and psychiatric disorders with respect to sex differences to provide a better understanding of caffeine use as a risk or protective factor for those disorders. The findings may help establish new strategies for developing sex-specific caffeine therapies.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu12103080