A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression

Highlights ► A non-secretory form of FAM3B named FAM3B-258 is uniquely and highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues. ► Overexpression of FAM3B-258 in colon cancer cells downregulates adhesion proteins, and upregulates Slug and Cdc42 expression. ► Overexp...

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Bibliographic Details
Published in:Cancer letters 2013-01, Vol.328 (2), p.278-284
Main Authors: Li, Zongmeng, Mou, Haiwei, Wang, Ting, Xue, Jing, Deng, Bo, Qian, Lihua, Zhou, Ye, Gong, Wanghua, Wang, Ji Ming, Wu, Guohao, Zhou, Cheng-Fu, Fang, Jing, Le, Yingying
Format: Article
Language:English
Subjects:
Acquisitions & mergers
adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
adhesion
Animals
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - metabolism
cell differentiation
cell invasion
Cell Line, Tumor
Cell migration
cell movement
Cell Movement - genetics
Colon cancer cell
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Colorectal cancer
colorectal neoplasms
correlation
Cytokines - genetics
Cytokines - metabolism
FAM3B variant
Female
Gastric cancer
Gene Expression
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
hepatoma
Humans
lung neoplasms
Male
Metastasis
Mice
Mortality
Neoplasm Invasiveness - genetics
Neoplasm Metastasis - genetics
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasm Staging
Proteins
RNA Isoforms - genetics
Rodents
Slug
Snail Family Transcription Factors
Studies
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Highlights ► A non-secretory form of FAM3B named FAM3B-258 is uniquely and highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues. ► Overexpression of FAM3B-258 in colon cancer cells downregulates adhesion proteins, and upregulates Slug and Cdc42 expression. ► Overexpression of FAM3B-258 in colon cancer cells promotes cell migration and invasion in vitro and metastasis in nude mice. ► FAM3B-258 downregulates adhesion molecules, upregulates Cdc42, and promotes invasion of colon cancer cells through Slug. ► The expression of FAM3B-258 is positively correlated with that of Slug in human colorectal adenocarcinomas.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.09.026