Quantitative Burden of COVID-19 Pneumonia on Chest CT Predicts Adverse Outcomes: A Post-Hoc Analysis of a Prospective International Registry

• Published in: Radiology. Cardiothoracic imaging 2020-10, Vol.2 (5), p.e200389
• Main Authors: Grodecki, Kajetan, Lin, Andrew, Cadet, Sebastien, McElhinney, Priscilla A, Razipour, Aryabod, Chan, Cato, Pressman, Barry, Julien, Peter, Maurovich-Horvat, Pal, Gaibazzi, Nicola, Thakur, Udit, Mancini, Elisabetta, Agalbato, Cecilia, Menè, Roberto, Parati, Gianfranco, Cernigliaro, Franco, Nerlekar, Nitesh, Torlasco, Camilla, Pontone, Gianluca, Slomka, Piotr J, Dey, Damini
• Format: Article
• Language: English
• Subjects: Original Research
• ISSN: 2638-6135; 2638-6135
• DOI: 10.1148/ryct.2020200389

To examine the independent and incremental value of CT-derived quantitative burden and attenuation of COVID-19 pneumonia for the prediction of clinical deterioration or death. This was a retrospective analysis of a prospective international registry of consecutive patients with laboratory-confirmed COVID-19 and chest CT imaging, admitted to four centers between January 10 and May 6, 2020. Total burden (expressed as a percentage) and mean attenuation of ground glass opacities (GGO) and consolidation were quantified from CT using semi-automated research software. The primary outcome was clinical deterioration (intensive care unit admission, invasive mechanical ventilation, or vasopressor therapy) or in-hospital death. Logistic regression was performed to assess the predictive value of clinical and CT parameters for the primary outcome. The final population comprised 120 patients (mean age 64 ± 16 years, 78 men), of whom 39 (32.5%) experienced clinical deterioration or death. In multivariable regression of clinical and CT parameters, consolidation burden (odds ratio [OR], 3.4; 95% confidence interval [CI]: 1.7, 6.9 per doubling; = .001) and increasing GGO attenuation (OR, 3.2; 95% CI: 1.3, 8.3 per standard deviation, = .02) were independent predictors of deterioration or death; as was C-reactive protein (OR, 2.1; 95% CI: 1.3, 3.4 per doubling; = .004), history of heart failure (OR 1.3; 95% CI: 1.1, 1.6, = .01), and chronic lung disease (OR, 1.3; 95% CI: 1.0, 1.6; = .02). Quantitative CT measures added incremental predictive value beyond a model with only clinical parameters (area under the curve, 0.93 vs 0.82, = .006). The optimal prognostic cutoffs for burden of COVID-19 pneumonia as determined by Youden's index were consolidation of greater than or equal to 1.8% and GGO of greater than or equal to 13.5%. Quantitative burden of consolidation or GGO on chest CT independently predict clinical deterioration or death in patients with COVID-19 pneumonia. CT-derived measures have incremental prognostic value over and above clinical parameters, and may be useful for risk stratifying patients with COVID-19.