Nephron number and its determinants: a 2020 update

Studies of human nephron number have been conducted for well over a century and have uncovered a large variability in nephron number. However, the mechanisms influencing nephron endowment and loss, along with the etiology for the wide range among individuals are largely unknown. Advances in imaging...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2021-04, Vol.36 (4), p.797-807
Main Authors: Charlton, Jennifer R., Baldelomar, Edwin J., Hyatt, Dylan M., Bennett, Kevin M.
Format: Article
Language:English
Subjects:
Educational Review
Etiology
Humans
Kidney
Kidney Diseases
Medicine
Medicine & Public Health
Nephrology
Nephrons
Pediatrics
Physiology
Renal function
Structure-function relationships
Technological change
Urology
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Summary:Studies of human nephron number have been conducted for well over a century and have uncovered a large variability in nephron number. However, the mechanisms influencing nephron endowment and loss, along with the etiology for the wide range among individuals are largely unknown. Advances in imaging technology have allowed investigators to revisit the principles of renal structure and physiology and their roles in the progression of kidney disease. Here, we will review the latest data on the influences impacting nephron number, innovations made over the last 6 years to understand and integrate renal structure and function, and new developments in the tools used to count nephrons in vivo.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-020-04534-2