Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl

Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. DNA methylation in blood fro...

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Bibliographic Details
Published in:Epigenomics 2020-05, Vol.12 (9), p.757-770
Main Authors: Curtis, Sarah W, Gerkowicz, Sabrina A, Cobb, Dawayland O, Kilaru, Varun, Terrell, Metrecia L, Marder, M Elizabeth, Barr, Dana Boyd, Marsit, Carmen J, Marcus, Michele, Conneely, Karen N, Smith, Alicia K
Format: Article
Language:English
Subjects:
DNA methylation
EDC
endocrine-disrupting compound
environmental health
epigenetics
epigenome-wide association study
EWAS
polybrominated biphenyl
sex differences
sex specific
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Summary:Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2019-0179