Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-sp...

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Bibliographic Details
Published in:International immunopharmacology 2021-01, Vol.90, p.107172-107172, Article 107172
Main Authors: Wei, Shuangshi, Duan, Shengbao, Liu, Xiaomei, Wang, Hongmei, Ding, Shaohua, Chen, Yezhou, Xie, Jinsong, Tian, Jingjing, Yu, Nong, Ge, pingju, Zhang, xinglin, chen, Xiaohong, Li, Yong, Meng, Qinglin
Format: Article
Language:English
Subjects:
ACE2
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - metabolism
Animals
Antibodies
Antibodies, Neutralizing - metabolism
Antibodies, Neutralizing - therapeutic use
Binding
Chicken Egg Yolk Antibodies
Chickens - immunology
Coronaviruses
COVID-19
COVID-19 - therapy
Egg Yolk - metabolism
Eggs
Humans
IgY
Immunoglobulins - metabolism
Immunoglobulins - therapeutic use
Mutants
Mutation - genetics
Neutralizing
Neutralizing agent
Pandemics
Protein Binding
Proteins
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - metabolism
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Short Communication
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - metabolism
Spike protein
Spike protein variants
Viral diseases
Viruses
Yolk
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Summary:The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2020.107172