Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

Environmental factors such as adverse childhood experiences (ACEs) may affect neurocognition, an endophenotype for several mental illnesses. This study examines the effect of ACEs on neurocognitive performance in first-degree relatives (FDRs) of patients with severe mental illness to determine wheth...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2022-12, Vol.119, p.110620-110620, Article 110620
Main Authors: Lakkireddy, Sai Priya, Balachander, Srinivas, Dayalamurthy, Pavithra, Bhattacharya, Mahashweta, Joseph, Mino Susan, Kumar, Pramod, Kannampuzha, Anand Jose, Mallappagari, Sreenivasulu, Narayana, Shruthi, Alexander, Alen Chandy, Moorthy, Muthukumaran, Sheth, Sweta, Puzhakkal, Joan C., Ramesh, Vinutha, Thatikonda, Navya Spurthi, Selvaraj, Sowmya, Ithal, Dhruva, Sreeraj, Vanteemar S., Mahadevan, Jayant, Holla, Bharath, Venkatasubramanian, Ganesan, John, John P., Murthy, Pratima, Benegal, Vivek, Reddy, Y.C. Janardhan, Jain, Sanjeev, Viswanath, Biju
Format: Article
Language:English
Subjects:
Abuse
ACEs
Adversity
Childhood deprivation
Childhood neglect
Childhood trauma
Cognitive performance
Familial risk
Maltreatment
Neurocognition
Neuropsychology
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Summary:Environmental factors such as adverse childhood experiences (ACEs) may affect neurocognition, an endophenotype for several mental illnesses. This study examines the effect of ACEs on neurocognitive performance in first-degree relatives (FDRs) of patients with severe mental illness to determine whether familial risk has a moderating effect on the relationship between ACEs and neurocognition. Unaffected FDRs from multiplex families with severe mental illnesses (schizophrenia, bipolar disorder, obsessive-compulsive disorder, or alcohol use disorder) (n = 324) and healthy controls (with no familial risk) (n = 188) underwent neurocognitive tests for processing speed, new learning, working memory and Theory of Mind. ACEs were measured using the WHO ACE-International Questionnaire (ACE-IQ). Regression models were done to predict each neurocognitive domain by the effect of familial risk, ACE-IQ Score and their interaction (familial risk*ACE-IQ score). The main effect of familial risk predicted poor performance in all domains of neurocognition (p 
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2022.110620