Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism in rats

The purpose of this study was to quantify the proanthocyanidin content of pecan ( ) pericarp extract (PPE) and to assess its useful impacts against carbon tetrachloride (CCl )-induced hepatotoxicity. Rats were randomly divided into four groups: Group 1: received intraperitoneal injection of saline s...

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Bibliographic Details
Published in:Toxicology research (Cambridge) 2020-09, Vol.9 (5), p.652-660
Main Authors: Dorsaf, Hallegue, Sabrine, Moujahed, Houda, Ben Lamine, Khémais, Ben Rhouma, Mohsen, Sakly, Olfa, Tebourbi
Format: Article
Language:English
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Summary:The purpose of this study was to quantify the proanthocyanidin content of pecan ( ) pericarp extract (PPE) and to assess its useful impacts against carbon tetrachloride (CCl )-induced hepatotoxicity. Rats were randomly divided into four groups: Group 1: received intraperitoneal injection of saline solution, Group 2: was injected with PPE (25 mg/kg body weight) for 10 consecutive days, Group 3: received CCl (0.5 ml/kg, subcutaneous injection), Group 4: was coadministred with PPE + CCl . The CCl was administered every 3 days during 10 days. Results revealed the presence of a high amount of total proanthocyanidins in the PPE (81.01 ± 0.21 mg TAE.g DW). CCl injection induced significant reductions in hepatic antioxidants but increased hepatic lipid peroxidation (LPO) as well as serum injury biomarkers. However, cotreatment with PPE significantly (  
ISSN:2045-452X
2045-4538
2045-4538
DOI:10.1093/toxres/tfaa071