Complete Blood Cell Count-Derived Inflammatory Biomarkers in Early-Stage Non-Small-Cell Lung Cancer

• Published in: Annals of Thoracic and Cardiovascular Surgery 2020, Vol.26(5), pp.248-255
• Main Authors: Shoji, Fumihiro, Kozuma, Yuka, Toyokawa, Gouji, Yamazaki, Koji, Takeo, Sadanori
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Blood Platelets - immunology; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; complete blood cell count-derived inflammatory biomarkers; Female; Humans; Inflammation - blood; Inflammation - diagnosis; Inflammation - immunology; Lung Neoplasms - blood; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lymphocyte Count; Lymphocytes - immunology; Male; Middle Aged; Monocytes - immunology; Neoplasm Recurrence, Local; Neoplasm Staging; Neutrophils - immunology; Original; pathological stage IA non-small-cell lung cancer; Platelet Count; Pneumonectomy; Predictive Value of Tests; prognostic factor; Retrospective Studies; Risk Factors; Treatment Outcome; Tumor Burden
• ISSN: 1341-1098; 2186-1005
• DOI: 10.5761/atcs.oa.19-00315

Background: Complete blood cell count (CBC)-derived inflammatory biomarkers are widely used as prognostic parameters for various malignancies, but the best predictive biomarker for early-stage non-small-cell lung cancer (NSCLC) is unclear. We retrospectively analyzed early-stage NSCLC patients to investigate predictive effects of preoperative CBC-derived inflammatory biomarkers.Patients and Methods: We selected 311 consecutive patients with pathological stage IA NSCLC surgically resected from April 2006 to December 2012. Univariate and multivariate Cox proportional analyses of recurrence-free survival (RFS) were used to test the preoperative systemic immune inflammation index (SII), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and monocyte–lymphocyte ratio (MLR).Results: Preoperative high MLR levels were significantly associated with patient sex, smoking status, and postoperative recurrence (p 2 cm had significantly shorter RFS than other subgroups (p = 0.0289).Conclusions: The preoperative MLR level is the optimal predictor of recurrence in patients with pathological stage IA NSCLC.