Differentiating esophageal sensitivity phenotypes using pH–impedance in intensive care unit infants referred for gastroesophageal reflux symptoms

Background To identify esophageal sensitivity phenotypes relative to acid (S Acid ), bolus (S Bolus ), acid and bolus (S Acid+Bolus ), and none (S None ) exposures in infants suspected with gastroesophageal reflux disease (GERD). Methods Symptomatic infants ( N  = 279) were evaluated for GERD at 42...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric research 2021-02, Vol.89 (3), p.636-644
Main Authors: Jadcherla, Sudarshan R., Sultana, Zakia, Hasenstab-Kenney, Kathryn A., Prabhakar, Varsha, Gulati, Ish K., Di Lorenzo, Carlo
Format: Article
Language:English
Subjects:
Acids
Clinical Research Article
Cough
Critical Care
Electric Impedance
Enteral Nutrition
Esophagus
Esophagus - metabolism
Esophagus - pathology
Female
Gastroesophageal reflux
Gastroesophageal Reflux - pathology
Humans
Hydrogen-Ion Concentration
Infant
Infant, Premature - physiology
Intensive Care Units
Intensive Care Units, Neonatal
Male
Medicine
Medicine & Public Health
Multivariate Analysis
Pediatric Surgery
Pediatrics
Phenotype
Probability
Sensitivity and Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background To identify esophageal sensitivity phenotypes relative to acid (S Acid ), bolus (S Bolus ), acid and bolus (S Acid+Bolus ), and none (S None ) exposures in infants suspected with gastroesophageal reflux disease (GERD). Methods Symptomatic infants ( N  = 279) were evaluated for GERD at 42 (40–45) weeks postmenstrual age using 24-h pH–impedance. Symptom-associated probability (SAP) for acid and bolus components defined esophageal sensitivity: (1) S Acid as SAP ≥ 95% for acid (pH 
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-020-0930-6