Iron out, mitophagy in! A way to slow down hepatocellular carcinoma

Mitochondrial homeostasis is necessary for the maintenance of cellular function and neuronal survival. Mitochondrial quality is tightly regulated by mitophagy, in which defective/superfluous mitochondria are degraded and recycled. Here, Hara et al demonstrate that induction of mitophagy via iron dep...

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Bibliographic Details
Published in:EMBO reports 2020-11, Vol.21 (11), p.e51652-n/a
Main Authors: Aman, Yahyah, Cao, Shuqin, Fang, Evandro F.
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - genetics
Depletion
EMBO07
EMBO24
EMBO57
Ferritins
Hepatocellular carcinoma
Homeostasis
Humans
Iron
Iron - metabolism
Liver cancer
Liver Neoplasms - genetics
Mitochondria
Mitophagy
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Summary:Mitochondrial homeostasis is necessary for the maintenance of cellular function and neuronal survival. Mitochondrial quality is tightly regulated by mitophagy, in which defective/superfluous mitochondria are degraded and recycled. Here, Hara et al demonstrate that induction of mitophagy via iron depletion suppresses the development of hepatocellular carcinoma (HCC). This work suggests turning up mitophagy as a potential therapeutic strategy against liver cancer. Graphical Abstract A study in this issue proposes turning up mitophagy via iron depletion as a potential therapeutic strategy against liver cancer.
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.202051652