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Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke

This study tested the hypothesis that abrogated dipeptidyl peptidase-4 (DPP4) activity played a crucial role on reducing stroke volume and preserving neurological function in rodent after acute hemorrhagic stroke (AHS). Animals (n=6/each group) were categorized into group 1 (sham-control of F344 rat...

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Bibliographic Details
Published in:International journal of biological sciences 2020-01, Vol.16 (16), p.3116-3132
Main Authors: Yip, Hon-Kan, Lee, Mel S, Li, Yi-Chen, Shao, Pei-Lin, Chiang, John Y, Sung, Pei-Hsun, Yang, Chien-Hui, Chen, Kuan-Hung
Format: Article
Language:English
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Summary:This study tested the hypothesis that abrogated dipeptidyl peptidase-4 (DPP4) activity played a crucial role on reducing stroke volume and preserving neurological function in rodent after acute hemorrhagic stroke (AHS). Animals (n=6/each group) were categorized into group 1 (sham-control of F344 rat), group 2 (sham-control of DPP4-deficiency rat), group 3 [AHS by right cerebral injection of autologous blood (100 µL) in F344 rat], group 4 (AHS + sitagliptin/600 mg/kg 3 h prior to and at 3 h then once per day after AHS) and group 5 (AHS in DPP4-deficiency rat). The results of corner test showed the neurological function was significantly improved from days 3, 7, and 14 in groups 4 and 5 than in group 3 (all
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.42677