Constipation and the Quality of Life in Conservatively Treated Chronic Kidney Disease Patients: A Cross-sectional Study

Constipation is a common gastrointestinal disorder that in general population is associated with worse health-related quality of life (HRQoL). The epidemiology of constipation has not been reliably determined in conservatively-treated CKD patients. We aimed to determine the prevalence of constipatio...

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Bibliographic Details
Published in:International journal of medical sciences 2020-01, Vol.17 (18), p.2954-2963
Main Authors: Ruszkowski, Jakub, Heleniak, Zbigniew, Król, Ewa, Tarasewicz, Agnieszka, Gałgowska, Joanna, Witkowski, Jacek M, Dębska-Ślizień, Alicja
Format: Article
Language:English
Subjects:
Age
Body mass index
Constipation
Cross-sectional studies
Defecation
Demographics
Hypertension
Hypothyroidism
Kidney diseases
Patients
Peritoneal dialysis
Population
Quality of life
Questionnaires
Research Paper
Statistical analysis
Variables
Visual impairment
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Summary:Constipation is a common gastrointestinal disorder that in general population is associated with worse health-related quality of life (HRQoL). The epidemiology of constipation has not been reliably determined in conservatively-treated CKD patients. We aimed to determine the prevalence of constipation and constipation-related symptoms in conservatively-treated CKD patients, to find factors associated with their altered prevalence ratio (PR), and to verify the associations between constipation and HRQoL. In this cross-sectional study, 111 conservatively-treated CKD outpatients fulfilled questionnaires that included questions addressing HRQoL (SF-36v2®), constipation-related symptoms (The Patient Assessment of Constipation-Symptoms questionnaire), the Bristol stool form scale (BSFS), Rome III criteria of functional constipation (FC), and frequency of bowel movement (BM). Depending on the used definition, the prevalence of constipation was 6.6-28.9%. Diuretics and paracetamol were independently associated with increased PR of BSFS-diagnosed constipation (PR 2.86, 95% CI 1.28-6.37, = 0.01) and FC (PR 2.67, 95% CI 1.07-6.64, = 0.035), respectively. The most commonly reported symptoms were bloating (50.9%) and straining to pass a BM (42.7%). Abdominal discomfort (37.3%) was independently associated with worse scores in all analyzed HRQoL domains. In multiple regressions, FC and having
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.49648