Optical Coherence Tomography Angiography Assessment of the Peripapillary Vessel Density and Structure in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy: A Meta-Analysis

Background. This meta-analysis is aimed at assessing the peripapillary vessel density (VD) and structural outcomes using optical coherence tomography angiography (OCTA) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. A comprehensive search of PubMed, Embase, Cochra...

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Published in:BioMed research international 2020, Vol.2020 (2020), p.1-11
Main Authors: Zhou, Wentian, Zhang, Qinglin, Gao, Feifei, Xie, Liping, Ji, Kaibao, Ling, Ling, Xing, Yiqiao
Format: Article
Language:English
Subjects:
Aged
Angiography
Blood vessels
Capillaries - pathology
Case-Control Studies
Confidence intervals
Density
Female
Fluorescein Angiography
Humans
Ischemia
Macula Lutea - pathology
Male
Medical examination
Medical imaging
Meta-analysis
Middle Aged
Optic neuropathy
Optic Neuropathy, Ischemic - diagnostic imaging
Optical Coherence Tomography
Optical tomography
Optics
Publication Bias
Retinal Ganglion Cells - pathology
Retinal Vessels - diagnostic imaging
Statistical analysis
Structure
Thickness
Tomography
Tomography, Optical Coherence
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Summary:Background. This meta-analysis is aimed at assessing the peripapillary vessel density (VD) and structural outcomes using optical coherence tomography angiography (OCTA) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases for literature comparing VD and structural outcomes in patients with NAION and controls was performed. Mean differences (MDs) and its 95% confidence interval (CI) were calculated for continuous estimates. Review Manager (V5.30) was used for analysis. Results. Fourteen published studies met the requirement. The radial peripapillary capillary (RPC) whole enface VD measured by OCTA was significantly lower in patients with NAION compared to that of the controls (MD=−10.51, P
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/1359120