Autophagy involvement in oncogenesis

Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of auto...

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Bibliographic Details
Published in:Cancer science 2020-11, Vol.111 (11), p.3993-3999
Main Authors: Torii, Satoru, Honda, Shinya, Murohashi, Michiko, Yamaguchi, Hirofumi, Shimizu, Shigeomi
Format: Article
Language:English
Subjects:
alternative autophagy
Animals
autophagic cell death
Autophagy
Biomarkers
Cancer
Cell adhesion & migration
Cell death
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
centrosome
Centrosome - metabolism
Disease Progression
Disease Susceptibility
Endoplasmic reticulum
Gene Expression Regulation, Neoplastic
Homeostasis
Humans
Kinases
Mammals
Membranes
Mutation
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
oncogenesis
Phagocytosis
Phosphatase
Phosphorylation
Proteins
Review
Signal Transduction
Tumorigenesis
Tumors
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Summary:Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical relationship between autophagy failure and oncogenesis. Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis. Here, we detail their mechanical relationship.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14646