Effects of Alkalization Therapy on Chemotherapy Outcomes in Advanced Pancreatic Cancer: A Retrospective Case-Control Study

BACKGROUND/AIMNeutralization of the acidic tumor microenvironment, which is associated with both progression and drug resistance of cancer cells, may be a new treatment option for progressing forms of cancer. We conducted a case-control study to investigate the effects of alkalization therapy, consi...

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Published in:In vivo (Athens) 2020-09, Vol.34 (5), p.2623-2629
Main Authors: HAMAGUCHI, REO, ITO, TAKASHI, NARUI, RYOKO, MORIKAWA, HIROMASA, UEMOTO, SHINJI, WADA, HIROMI
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container_end_page 2629
container_issue 5
container_start_page 2623
container_title In vivo (Athens)
container_volume 34
creator HAMAGUCHI, REO
ITO, TAKASHI
NARUI, RYOKO
MORIKAWA, HIROMASA
UEMOTO, SHINJI
WADA, HIROMI
description BACKGROUND/AIMNeutralization of the acidic tumor microenvironment, which is associated with both progression and drug resistance of cancer cells, may be a new treatment option for progressing forms of cancer. We conducted a case-control study to investigate the effects of alkalization therapy, consisting of an alkaline diet with supplementary oral sodium bicarbonate, in patients with metastatic or recurrent pancreatic cancer (study registration no.: UMIN000036126). PATIENTS AND METHODSThirty-six patients in the alkalization group (Karasuma Wada Clinic; alkalization therapy plus chemotherapy) were retrospectively compared to 89 patients in the control group (Kyoto University Hospital; chemotherapy only). RESULTSThe median overall survival (OS) in the alkalization group was significantly longer than that in the control group (15.4 vs. 10.8 months; p1.0) in the alkalization group was significantly longer than that of the control group. CONCLUSIONAlkalization therapy may enhance the effects of chemotherapy in patients with advanced pancreatic cancer.
doi_str_mv 10.21873/invivo.12080
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We conducted a case-control study to investigate the effects of alkalization therapy, consisting of an alkaline diet with supplementary oral sodium bicarbonate, in patients with metastatic or recurrent pancreatic cancer (study registration no.: UMIN000036126). PATIENTS AND METHODSThirty-six patients in the alkalization group (Karasuma Wada Clinic; alkalization therapy plus chemotherapy) were retrospectively compared to 89 patients in the control group (Kyoto University Hospital; chemotherapy only). RESULTSThe median overall survival (OS) in the alkalization group was significantly longer than that in the control group (15.4 vs. 10.8 months; p&lt;0.005). In the alkalization group, mean urine pH was significantly increased after alkalization therapy [6.38±0.85 (before) vs. 6.80±0.71 (after); p&lt;0.05]. Furthermore, the median OS of patients with increased urine pH (pH&gt;7.0 or ΔpH&gt;1.0) in the alkalization group was significantly longer than that of the control group. 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We conducted a case-control study to investigate the effects of alkalization therapy, consisting of an alkaline diet with supplementary oral sodium bicarbonate, in patients with metastatic or recurrent pancreatic cancer (study registration no.: UMIN000036126). PATIENTS AND METHODSThirty-six patients in the alkalization group (Karasuma Wada Clinic; alkalization therapy plus chemotherapy) were retrospectively compared to 89 patients in the control group (Kyoto University Hospital; chemotherapy only). RESULTSThe median overall survival (OS) in the alkalization group was significantly longer than that in the control group (15.4 vs. 10.8 months; p&lt;0.005). In the alkalization group, mean urine pH was significantly increased after alkalization therapy [6.38±0.85 (before) vs. 6.80±0.71 (after); p&lt;0.05]. Furthermore, the median OS of patients with increased urine pH (pH&gt;7.0 or ΔpH&gt;1.0) in the alkalization group was significantly longer than that of the control group. 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We conducted a case-control study to investigate the effects of alkalization therapy, consisting of an alkaline diet with supplementary oral sodium bicarbonate, in patients with metastatic or recurrent pancreatic cancer (study registration no.: UMIN000036126). PATIENTS AND METHODSThirty-six patients in the alkalization group (Karasuma Wada Clinic; alkalization therapy plus chemotherapy) were retrospectively compared to 89 patients in the control group (Kyoto University Hospital; chemotherapy only). RESULTSThe median overall survival (OS) in the alkalization group was significantly longer than that in the control group (15.4 vs. 10.8 months; p&lt;0.005). In the alkalization group, mean urine pH was significantly increased after alkalization therapy [6.38±0.85 (before) vs. 6.80±0.71 (after); p&lt;0.05]. Furthermore, the median OS of patients with increased urine pH (pH&gt;7.0 or ΔpH&gt;1.0) in the alkalization group was significantly longer than that of the control group. 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title Effects of Alkalization Therapy on Chemotherapy Outcomes in Advanced Pancreatic Cancer: A Retrospective Case-Control Study
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