Acrophyseal growth arrest in a long-term survivor of acute lymphoblastic leukemia

Growth arrest at the secondary growth plate, also known as the acrophysis, is a rare phenomenon with only very few known published case reports. We report on a case of formation of ghost secondary ossification centers at the acrophyses of the knee joint in a 14-year-old female, who survived early ch...

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Bibliographic Details
Published in:Skeletal radiology 2020-12, Vol.49 (12), p.2095-2099
Main Authors: de Rooy, Jacky, Buckens, Stan, Brons, Paul M., van der Geest, Ingrid, Vanhoenacker, Filip
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Adolescent
Bone and Bones
Bone growth
Care and treatment
Case Report
Case reports
Children
Chronic pain
Complications
Disodium pamidronate
Endochondral bone
Female
Growth Plate
Humans
Imaging
Immobilization
Knee
Leukemia
Lymphatic leukemia
Magnetic resonance imaging
Medicine
Medicine & Public Health
Meniscus
Nuclear Medicine
Orthopedics
Ossification
Pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging
Radiographs
Radiography
Radiology
Side effects
Survivors
Vincristine
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Summary:Growth arrest at the secondary growth plate, also known as the acrophysis, is a rare phenomenon with only very few known published case reports. We report on a case of formation of ghost secondary ossification centers at the acrophyses of the knee joint in a 14-year-old female, who survived early childhood acute lymphoblastic leukemia. The patient suffered from severe side effects from both disease and subsequent treatment strategies with a 10-month immobilization period as a consequence at the age of 3 years. The ghost secondary ossification centers were encountered on radiographs and MRI 10 years later, when she presented for evaluation of chronic pain in her left knee related to sports activities, due to a meniscal cyst. Awareness of this phenomenon is nevertheless important, because it seems that endochondral bone growth recovery at the acrophyses might be different from recovery in physes, because we found no concomitant sequelae of growth arrest in the metaphyses.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-020-03513-w