The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ

• Published in: British journal of cancer 2020-11, Vol.123 (10), p.1513-1520
• Main Authors: Miligy, Islam M., Toss, Michael S., Shiino, Sho, Oni, Georgette, Syed, Binafsha M., Khout, Hazem, Tan, Qing Ting, Green, Andrew R., Macmillan, R. Douglas, Robertson, John F. R., Rakha, Emad A.
• Format: Article
• Language: English
• Subjects: 631/67/1347; 692/4028/67/1347; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal - therapeutic use; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Cancer Research; Carcinoma in Situ - diagnosis; Carcinoma in Situ - drug therapy; Carcinoma in Situ - metabolism; Carcinoma in Situ - mortality; Carcinoma, Ductal, Breast - diagnosis; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - mortality; Chemotherapy, Adjuvant; Clinical significance; Cohort Studies; Drug Resistance; Endocrine therapy; Epidemiology; Female; Hospitals; Humans; Invasiveness; Mastectomy; Medical prognosis; Medical research; Medicine; Metastasis; Middle Aged; Molecular Medicine; Mortality; Oncology; Predictive Value of Tests; Prognosis; Receptors, Estrogen - analysis; Receptors, Estrogen - metabolism; Retrospective Studies; Surgery; Survival Analysis; Tissue Array Analysis; Treatment Outcome; Tumors; Womens health
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/s41416-020-1023-3

Background Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of outcome and the impact on ET decision. Methods In total, 643 pure DCIS, diagnosed at Nottingham University Hospitals, were assessed for ER. Clinicopathological data were correlated against ER status, together with assessment of recurrence rate. Results ER positivity was observed in 74% (475/643) of cases. ER positivity was associated with clinicopathological variables of good prognosis; however, outcome analysis revealed that ER status was not associated with local recurrence. In the intermediate- and high-grade ER-positive DCIS, 58% (11/19) and 63% (15/24) of the recurrences were invasive, respectively, comprising 7% and 6% of all ER-positive DCIS, respectively. Invasive recurrence in low-grade DCIS was infrequent (2%), and none of these patients died of BC. The ER status of the recurrent invasive tumours matched the primary DCIS ER status (94% in ipsilateral and 90% of contralateral recurrence). Conclusion The strong correlation between DCIS and invasive recurrence ER status and the clinical impact of ET justify discussion of the use of ET in ER-positive DCIS treated by breast-conserving surgery. The excellent outcome of low-grade DCIS, which was almost always ER-positive, does not, in the opinion of authors, justify the use of risk-reducing ET. Therefore, the decision on ET for DCIS should be personalised and consider grade, ER status and other characteristics.