Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome

• Published in: Scientific reports 2020-11, Vol.10 (1), p.19325-19325, Article 19325
• Main Authors: Maziotis, E., Sfakianoudis, K., Giannelou, P., Grigoriadis, S., Rapani, A., Tsioulou, P., Nikolettos, K., Pantou, A., Tiptiri-Kourpeti, A., Koutsilieris, M., Asimakopoulos, B., Nikolettos, N., Pantos, K., Simopoulou, Mara
• Format: Article
• Language: English
• Subjects: 631/136/1455; 631/136/2086; Adult; Birth Rate; Cryopreservation; Developmental stages; Embryo Transfer; Embryos; Female; Fertilization; Fertilization in Vitro - methods; Humanities and Social Sciences; Humans; Infertility - therapy; Laboratories; Male; multidisciplinary; Observational studies; Oocytes; Oocytes - cytology; Ovulation Induction; Polar Bodies - physiology; Prediction models; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Prospective Studies; Science; Science (multidisciplinary); Sperm Injections, Intracytoplasmic - methods; Treatment Outcome; Zona Pellucida - physiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-75164-9

A number of oocyte characteristics have been associated with fertilization, implantation and live-birth rates, albeit without reaching a consensus. This study aims to delineate possible associations between oocyte characteristics, oocyte behavior during intracytoplasmic sperm injection (ICSI), fertilization potential, and laboratory outcomes. Four-hundred and seventy-seven patients, yielding 3452 oocytes, were enrolled in this prospective observational study from 2015 to 2018. Οoplasm granularity was associated with poor embryo quality and higher probabilities of post-ICSI oocytes and embryos discarded in any developmental stage and never selected for embryo transfer or cryopreservation ( p