miRNA degradation in the mammalian brain

MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2020-10, Vol.319 (4), p.C624-C629
Main Authors: Kim, Chun K, Pak, Toni R
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain - pathology
Degradation
Gene expression
Homeostasis
Homeostasis - genetics
Humans
Mammals
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Mini-Review
miRNA
Neurons - metabolism
RNA Stability - genetics
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Summary:MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing research. This review focuses on recent findings concerning the cellular mechanisms that govern miRNA degradation, with an emphasis on target-mediated miRNA degradation and how this phenomenon is uniquely poised to maintain homeostasis in neuronal systems.
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.00303.2020