Loading…
Endocrine-sensitive physical endpoints in newborns: ranges and predictors
Background In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure. Studies using standardized measurement techniques that describe demographic and clinical variability in these endpoints are lacking. Methods...
Saved in:
| Published in: | Pediatric research 2021-02, Vol.89 (3), p.660-666 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3 |
| container_end_page | 666 |
| container_issue | 3 |
| container_start_page | 660 |
| container_title | Pediatric research |
| container_volume | 89 |
| creator | Shah, Rachana Alshaikh, Belal Schall, Joan I. Kelly, Andrea Ford, Eileen Zemel, Babette S. Umbach, David M. Adgent, Margaret Stallings, Virginia A. |
| description | Background
In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure. Studies using standardized measurement techniques that describe demographic and clinical variability in these endpoints are lacking.
Methods
Three hundred and eighty-eight healthy term newborns |
| doi_str_mv | 10.1038/s41390-020-0950-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7657971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2503046612</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_gBdZ8Lya72w8CFKqFgQveg7ZJG0jNVmTrdJ_b0rr18HDMAzzzvsODwCnCF4gSJrLTBGRsIa4lGSwxntgiBgpE6ViHwwhJKgmUjYDcJTzC4SIsoYeggHBRHKJ-RBMJ8FGk3xwdXYh-96_u6pbrLM3elm5YLvoQ58rH6rgPtqYQr6qkg5zlysdbNUlZ73pY8rH4GCml9md7PoIPN9Onsb39cPj3XR881AbRnhfE2gENUg6iy3TspkxJ7ThArWMSNoQawmTQlozExg6KWnLhUS85bKF3NGWjMD11rdbta_OGhf6pJeqS_5Vp7WK2qu_m-AXah7fleBMSIGKwfnOIMW3lcu9eomrFMrPCjNIIOUc4aJCW5VJMefkZt8JCKoNfbWlrwp9taGvNjdnv1_7vvjCXQR4K8hlVRimn-j_XT8BTR2RBw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2503046612</pqid></control><display><type>article</type><title>Endocrine-sensitive physical endpoints in newborns: ranges and predictors</title><source>Springer Link</source><creator>Shah, Rachana ; Alshaikh, Belal ; Schall, Joan I. ; Kelly, Andrea ; Ford, Eileen ; Zemel, Babette S. ; Umbach, David M. ; Adgent, Margaret ; Stallings, Virginia A.</creator><creatorcontrib>Shah, Rachana ; Alshaikh, Belal ; Schall, Joan I. ; Kelly, Andrea ; Ford, Eileen ; Zemel, Babette S. ; Umbach, David M. ; Adgent, Margaret ; Stallings, Virginia A.</creatorcontrib><description>Background
In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure. Studies using standardized measurement techniques that describe demographic and clinical variability in these endpoints are lacking.
Methods
Three hundred and eighty-eight healthy term newborns <3 days old were evaluated, 69% African American and 25% White. Measures included breast bud diameter, anogenital distance (AGD), stretched penile length (SPL), and testicular volume (TV).
Results
Breast buds were larger in females than males bilaterally (right: 13.0 ± 4.0 vs. 12.0 ± 4.0 mm,
p
= 0.008; left: 13.0 ± 4.0 vs. 11.0 ± 3.0 mm,
p
< 0.001). Breast bud size correlated positively with gestational age (regression coefficient = 0.46 ± 0.12 mm,
p
< 0.001) and weight
Z
-score (0.59 ± 0.24 mm,
p
= 0.02), and negatively with White race (−1.00 ± 0.30 mm,
p
= 0.001). AGD was longer in males (scrotum-to-anus) than females (fourchette-to-anus) (21.0 ± 4.0 vs. 13.0 ± 2.0 mm,
p
< 0.001) and did not differ by race. SPL was shorter in White infants (35.0 ± 5.0 vs. 36.0 ± 5.0 mm,
p
= 0.04). Median TV was 0.5 cm
3
, and larger in White males (odds ratio 1.71, 95% confidence interval: 1.02–2.88)
Conclusions
This study provides a range of physical measurements of endocrine-sensitive tissues in healthy infants from the United States, and the associations with demographic and clinical characteristics.
Impact
This study reports physical measurements for endocrine-sensitive endpoints in healthy US newborns, including breast buds, AGD, SPL, and TV.
Associations of measurements to demographic and clinical factors (including race, gestational age, and newborn length and weight) are presented.
Contemporary ranges and identification of predictive factors will support further study on effects of pre- and postnatal exposures to endocrine-sensitive tissues in the infant.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-0950-2</identifier><identifier>PMID: 32396926</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>African Americans ; Animals ; Breast - anatomy & histology ; Breast - physiology ; Clinical Research Article ; Endocrine Disruptors ; Endocrine System - physiology ; Environmental Exposure ; Female ; Gestational age ; Humans ; Infant Formula ; Infant, Newborn ; Male ; Measurement techniques ; Medicine ; Medicine & Public Health ; Milk ; Milk, Human ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Penis - anatomy & histology ; Penis - physiology ; Reproducibility of Results ; Testis - anatomy & histology ; Testis - physiology ; Whites</subject><ispartof>Pediatric research, 2021-02, Vol.89 (3), p.660-666</ispartof><rights>International Pediatric Research Foundation, Inc 2020</rights><rights>International Pediatric Research Foundation, Inc 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3</citedby><cites>FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3</cites><orcidid>0000-0001-7866-557X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32396926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Rachana</creatorcontrib><creatorcontrib>Alshaikh, Belal</creatorcontrib><creatorcontrib>Schall, Joan I.</creatorcontrib><creatorcontrib>Kelly, Andrea</creatorcontrib><creatorcontrib>Ford, Eileen</creatorcontrib><creatorcontrib>Zemel, Babette S.</creatorcontrib><creatorcontrib>Umbach, David M.</creatorcontrib><creatorcontrib>Adgent, Margaret</creatorcontrib><creatorcontrib>Stallings, Virginia A.</creatorcontrib><title>Endocrine-sensitive physical endpoints in newborns: ranges and predictors</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure. Studies using standardized measurement techniques that describe demographic and clinical variability in these endpoints are lacking.
Methods
Three hundred and eighty-eight healthy term newborns <3 days old were evaluated, 69% African American and 25% White. Measures included breast bud diameter, anogenital distance (AGD), stretched penile length (SPL), and testicular volume (TV).
Results
Breast buds were larger in females than males bilaterally (right: 13.0 ± 4.0 vs. 12.0 ± 4.0 mm,
p
= 0.008; left: 13.0 ± 4.0 vs. 11.0 ± 3.0 mm,
p
< 0.001). Breast bud size correlated positively with gestational age (regression coefficient = 0.46 ± 0.12 mm,
p
< 0.001) and weight
Z
-score (0.59 ± 0.24 mm,
p
= 0.02), and negatively with White race (−1.00 ± 0.30 mm,
p
= 0.001). AGD was longer in males (scrotum-to-anus) than females (fourchette-to-anus) (21.0 ± 4.0 vs. 13.0 ± 2.0 mm,
p
< 0.001) and did not differ by race. SPL was shorter in White infants (35.0 ± 5.0 vs. 36.0 ± 5.0 mm,
p
= 0.04). Median TV was 0.5 cm
3
, and larger in White males (odds ratio 1.71, 95% confidence interval: 1.02–2.88)
Conclusions
This study provides a range of physical measurements of endocrine-sensitive tissues in healthy infants from the United States, and the associations with demographic and clinical characteristics.
Impact
This study reports physical measurements for endocrine-sensitive endpoints in healthy US newborns, including breast buds, AGD, SPL, and TV.
Associations of measurements to demographic and clinical factors (including race, gestational age, and newborn length and weight) are presented.
Contemporary ranges and identification of predictive factors will support further study on effects of pre- and postnatal exposures to endocrine-sensitive tissues in the infant.</description><subject>African Americans</subject><subject>Animals</subject><subject>Breast - anatomy & histology</subject><subject>Breast - physiology</subject><subject>Clinical Research Article</subject><subject>Endocrine Disruptors</subject><subject>Endocrine System - physiology</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Gestational age</subject><subject>Humans</subject><subject>Infant Formula</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Measurement techniques</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Milk</subject><subject>Milk, Human</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Penis - anatomy & histology</subject><subject>Penis - physiology</subject><subject>Reproducibility of Results</subject><subject>Testis - anatomy & histology</subject><subject>Testis - physiology</subject><subject>Whites</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMotlZ_gBdZ8Lya72w8CFKqFgQveg7ZJG0jNVmTrdJ_b0rr18HDMAzzzvsODwCnCF4gSJrLTBGRsIa4lGSwxntgiBgpE6ViHwwhJKgmUjYDcJTzC4SIsoYeggHBRHKJ-RBMJ8FGk3xwdXYh-96_u6pbrLM3elm5YLvoQ58rH6rgPtqYQr6qkg5zlysdbNUlZ73pY8rH4GCml9md7PoIPN9Onsb39cPj3XR881AbRnhfE2gENUg6iy3TspkxJ7ThArWMSNoQawmTQlozExg6KWnLhUS85bKF3NGWjMD11rdbta_OGhf6pJeqS_5Vp7WK2qu_m-AXah7fleBMSIGKwfnOIMW3lcu9eomrFMrPCjNIIOUc4aJCW5VJMefkZt8JCKoNfbWlrwp9taGvNjdnv1_7vvjCXQR4K8hlVRimn-j_XT8BTR2RBw</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Shah, Rachana</creator><creator>Alshaikh, Belal</creator><creator>Schall, Joan I.</creator><creator>Kelly, Andrea</creator><creator>Ford, Eileen</creator><creator>Zemel, Babette S.</creator><creator>Umbach, David M.</creator><creator>Adgent, Margaret</creator><creator>Stallings, Virginia A.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7866-557X</orcidid></search><sort><creationdate>20210201</creationdate><title>Endocrine-sensitive physical endpoints in newborns: ranges and predictors</title><author>Shah, Rachana ; Alshaikh, Belal ; Schall, Joan I. ; Kelly, Andrea ; Ford, Eileen ; Zemel, Babette S. ; Umbach, David M. ; Adgent, Margaret ; Stallings, Virginia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>African Americans</topic><topic>Animals</topic><topic>Breast - anatomy & histology</topic><topic>Breast - physiology</topic><topic>Clinical Research Article</topic><topic>Endocrine Disruptors</topic><topic>Endocrine System - physiology</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Gestational age</topic><topic>Humans</topic><topic>Infant Formula</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Measurement techniques</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Milk</topic><topic>Milk, Human</topic><topic>Newborn babies</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Penis - anatomy & histology</topic><topic>Penis - physiology</topic><topic>Reproducibility of Results</topic><topic>Testis - anatomy & histology</topic><topic>Testis - physiology</topic><topic>Whites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Rachana</creatorcontrib><creatorcontrib>Alshaikh, Belal</creatorcontrib><creatorcontrib>Schall, Joan I.</creatorcontrib><creatorcontrib>Kelly, Andrea</creatorcontrib><creatorcontrib>Ford, Eileen</creatorcontrib><creatorcontrib>Zemel, Babette S.</creatorcontrib><creatorcontrib>Umbach, David M.</creatorcontrib><creatorcontrib>Adgent, Margaret</creatorcontrib><creatorcontrib>Stallings, Virginia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Rachana</au><au>Alshaikh, Belal</au><au>Schall, Joan I.</au><au>Kelly, Andrea</au><au>Ford, Eileen</au><au>Zemel, Babette S.</au><au>Umbach, David M.</au><au>Adgent, Margaret</au><au>Stallings, Virginia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine-sensitive physical endpoints in newborns: ranges and predictors</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>89</volume><issue>3</issue><spage>660</spage><epage>666</epage><pages>660-666</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure. Studies using standardized measurement techniques that describe demographic and clinical variability in these endpoints are lacking.
Methods
Three hundred and eighty-eight healthy term newborns <3 days old were evaluated, 69% African American and 25% White. Measures included breast bud diameter, anogenital distance (AGD), stretched penile length (SPL), and testicular volume (TV).
Results
Breast buds were larger in females than males bilaterally (right: 13.0 ± 4.0 vs. 12.0 ± 4.0 mm,
p
= 0.008; left: 13.0 ± 4.0 vs. 11.0 ± 3.0 mm,
p
< 0.001). Breast bud size correlated positively with gestational age (regression coefficient = 0.46 ± 0.12 mm,
p
< 0.001) and weight
Z
-score (0.59 ± 0.24 mm,
p
= 0.02), and negatively with White race (−1.00 ± 0.30 mm,
p
= 0.001). AGD was longer in males (scrotum-to-anus) than females (fourchette-to-anus) (21.0 ± 4.0 vs. 13.0 ± 2.0 mm,
p
< 0.001) and did not differ by race. SPL was shorter in White infants (35.0 ± 5.0 vs. 36.0 ± 5.0 mm,
p
= 0.04). Median TV was 0.5 cm
3
, and larger in White males (odds ratio 1.71, 95% confidence interval: 1.02–2.88)
Conclusions
This study provides a range of physical measurements of endocrine-sensitive tissues in healthy infants from the United States, and the associations with demographic and clinical characteristics.
Impact
This study reports physical measurements for endocrine-sensitive endpoints in healthy US newborns, including breast buds, AGD, SPL, and TV.
Associations of measurements to demographic and clinical factors (including race, gestational age, and newborn length and weight) are presented.
Contemporary ranges and identification of predictive factors will support further study on effects of pre- and postnatal exposures to endocrine-sensitive tissues in the infant.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32396926</pmid><doi>10.1038/s41390-020-0950-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7866-557X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2021-02, Vol.89 (3), p.660-666 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7657971 |
| source | Springer Link |
| subjects | African Americans Animals Breast - anatomy & histology Breast - physiology Clinical Research Article Endocrine Disruptors Endocrine System - physiology Environmental Exposure Female Gestational age Humans Infant Formula Infant, Newborn Male Measurement techniques Medicine Medicine & Public Health Milk Milk, Human Newborn babies Pediatric Surgery Pediatrics Penis - anatomy & histology Penis - physiology Reproducibility of Results Testis - anatomy & histology Testis - physiology Whites |
| title | Endocrine-sensitive physical endpoints in newborns: ranges and predictors |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A53%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endocrine-sensitive%20physical%20endpoints%20in%20newborns:%20ranges%20and%20predictors&rft.jtitle=Pediatric%20research&rft.au=Shah,%20Rachana&rft.date=2021-02-01&rft.volume=89&rft.issue=3&rft.spage=660&rft.epage=666&rft.pages=660-666&rft.issn=0031-3998&rft.eissn=1530-0447&rft_id=info:doi/10.1038/s41390-020-0950-2&rft_dat=%3Cproquest_pubme%3E2503046612%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c536t-30c74c19ed2d5a98f5e7ac671b539483dd35979dcf720e994b67916b69b06e4b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2503046612&rft_id=info:pmid/32396926&rfr_iscdi=true |