Dual-Mode Solution Plasma Processing for the Production of Chitosan/Ag Composites with the Antibacterial Effect

The development of novel biocompatible and biodegradable materials for medical applications has been drawing significant interest in the scientific community for years. Particularly, chitosan loaded with silver nanoparticles (Ag NPs) has a strong antimicrobial potential and could be applied, for exa...

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Bibliographic Details
Published in:Materials 2020-11, Vol.13 (21), p.4821
Main Authors: Titov, Valerii, Nikitin, Daniil, Naumova, Irina, Losev, Nikolay, Lipatova, Irina, Kosterin, Dmitry, Pleskunov, Pavel, Perekrestov, Roman, Sirotkin, Nikolay, Khlyustova, Anna, Agafonov, Alexander, Choukourov, Andrei
Format: Article
Language:English
Subjects:
Anodes
Anodizing
Antiinfectives and antibacterials
Biocompatibility
Biodegradability
Cathodes
Cellulose
Chitosan
Composite materials
Direct current
E coli
Electrodes
Glass substrates
Glow discharges
Hydrogen peroxide
Medical materials
Molecular weight
Nanoparticles
Oxidation
Plasma
Plasma processing
Silver
Silver nitrate
Viscosity
Wound healing
Zinc oxides
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Summary:The development of novel biocompatible and biodegradable materials for medical applications has been drawing significant interest in the scientific community for years. Particularly, chitosan loaded with silver nanoparticles (Ag NPs) has a strong antimicrobial potential and could be applied, for example, as wound dressing material. In this work, chitosan/Ag NP composites were produced utilizing a single-step plasma-solution process, which is simple and environmentally friendly. An acetic solution of chitosan containing AgNO3 was treated by the direct current (DC) atmospheric pressure glow discharge, with the liquid serving as either cathode or anode. The plasma-solution system with liquid anode is more useful for the production of Ag NPs. Nevertheless, the NP size is comparable for both cases. The plasma treatment with both polarities led to chitosan degradation. The cleavage of glucosidic chains mostly occurred in the system with the liquid cathode, whereas the side oxidation reactions took place when the solution served as the anode. The oxidation processes were possibly induced by the hydrogen peroxide H2O2 efficiently formed in the last case. The composite materials produced with both polarities of liquid electrode demonstrated the bactericidal action against Gram-negative Escherichia coli, Gram-positive Staphylococcus aureus, and Gram-positive Bacillus subtilis.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma13214821