The Role of CASC2 and miR-21 Interplay in Glioma Malignancy and Patient Outcome

Recently long non-coding RNAs (lncRNAs) were highlighted for their regulatory role in tumor biology. The novel human lncRNA cancer susceptibility candidate 2 ( ) has been characterized as a potential tumor suppressor in several tumor types. However, the roles of and its interplay with in different m...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-10, Vol.21 (21), p.7962
Main Authors: Skiriute, Daina, Stakaitis, Rytis, Steponaitis, Giedrius, Tamasauskas, Arimantas, Vaitkiene, Paulina
Format: Article
Language:English
Subjects:
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Cell growth
Clinical outcomes
Colorectal cancer
DNA Methylation
DNA Modification Methylases - genetics
DNA Repair Enzymes - genetics
Down-Regulation
Female
Gene expression
Gene Expression Regulation, Neoplastic
Glioma
Glioma - genetics
Glioma - pathology
Humans
Isocitrate dehydrogenase
Isocitrate Dehydrogenase - genetics
Male
Malignancy
Metastasis
Methylguanine
MicroRNAs
MicroRNAs - genetics
Neoplasm Grading
Non-coding RNA
O6-methylguanine-DNA methyltransferase
Patients
Polymerase chain reaction
Promoter Regions, Genetic
Survival Analysis
Tumor suppressor genes
Tumor Suppressor Proteins - genetics
Tumors
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Summary:Recently long non-coding RNAs (lncRNAs) were highlighted for their regulatory role in tumor biology. The novel human lncRNA cancer susceptibility candidate 2 ( ) has been characterized as a potential tumor suppressor in several tumor types. However, the roles of and its interplay with in different malignancy grade patient gliomas remain unexplored. Here we screened 99 different malignancy grade astrocytomas for , and gene expression by real-time quantitative polymerase chain reaction (RT-qPCR) in isocitrate dehydrogenase 1 ( ) and O-6-methylguanine methyltransferase ( ) assessed gliomas. expression was significantly downregulated in glioblastomas ( = 0.0003). Gliomas with low expression exhibited a high level of , which was highly associated with the higher glioma grade ( = 0.0001), gliomas ( < 0.0001), and poor patient survival ( < 0.001). Taken together, these observations suggest that acts as a tumor suppressor and potentially as a competing endogenous RNA (ceRNA) for plays important role in glioma pathogenesis and patients' outcomes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21217962