Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection

Abstract Aims  To elucidate the prognostic role of monocytes in the immune response of patients with coronary artery disease (CAD) at risk for life-threatening heart and lung injury as major complications of SARS-CoV-2 infection. Methods and results  From February to April 2020, we prospectively stu...

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Bibliographic Details
Published in:Cardiovascular research 2021-01, Vol.117 (1), p.224-239
Main Authors: Mueller, Karin Anne Lydia, Langnau, Carolin, Günter, Manina, Pöschel, Simone, Gekeler, Sarah, Petersen-Uribe, Álvaro, Kreisselmeier, Klaus-Peter, Klingel, Karin, Bösmüller, Hans, Li, Bo, Jaeger, Philippa, Castor, Tatsiana, Rath, Dominik, Gawaz, Meinrad Paul, Autenrieth, Stella E
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Coronary Artery Disease - complications
Coronary Artery Disease - immunology
COVID-19 - complications
COVID-19 - immunology
Female
GPI-Linked Proteins - analysis
Humans
Immunohistochemistry
Lipopolysaccharide Receptors - analysis
Male
Middle Aged
Monocytes - immunology
Monocytes - physiology
Original
Phenotype
Receptors, IgG - analysis
Retrospective Studies
SARS-CoV-2
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Summary:Abstract Aims  To elucidate the prognostic role of monocytes in the immune response of patients with coronary artery disease (CAD) at risk for life-threatening heart and lung injury as major complications of SARS-CoV-2 infection. Methods and results  From February to April 2020, we prospectively studied a cohort of 96 participants comprising 47 consecutive patients with CAD and acute SARS-CoV-2 infection (CAD + SARS-CoV-2), 19 CAD patients without infections, and 30 healthy controls. Clinical assessment included blood sampling, echocardiography, and electrocardiography within 12 h of admission. Respiratory failure was stratified by the Horovitz Index (HI) as moderately/severely impaired when HI ≤200 mmHg. The clinical endpoint (EP) was defined as HI ≤200 mmHg with subsequent mechanical ventilation within a follow-up of 30 days. The numbers of CD14dimCD16+ non-classical monocytes in peripheral blood were remarkably low in CAD + SARS-CoV-2 compared with CAD patients without infection and healthy controls (P 
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvaa328