CYFRA21-1/TG ratio as an accurate risk factor to predict eye metastasis in nasopharyngeal carcinoma: A STROBE-compliant article

Nasopharyngeal carcinoma (NPC) has a distinctive geographical distribution in China, especially southern China. There are several risk factors for NPC, such as Epstein-Barr virus, genetics, and environmental exposures. Although the incidence of eye metastasis (EM) is lower than metastasis in other b...

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Bibliographic Details
Published in:Medicine (Baltimore) 2020-11, Vol.99 (46), p.e22773-e22773
Main Authors: Peng, Sheng-Jia, Wang, Chu-Feng, Yu, Ya-Jie, Yu, Chen-Yu, Chen, Si-Yi, Wu, Shi-Nan, Tan, Si-Wen, Peng, Jia-Xin, Li, Biao, Shao, Yi
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - analysis
Antigens, Neoplasm - blood
Biomarkers, Tumor - analysis
China - epidemiology
Eye Neoplasms - epidemiology
Eye Neoplasms - etiology
Eye Neoplasms - genetics
Female
Humans
Keratin-19 - analysis
Keratin-19 - blood
Logistic Models
Male
Middle Aged
Nasopharyngeal Neoplasms - epidemiology
Nasopharyngeal Neoplasms - genetics
Neoplasm Metastasis - diagnosis
Neoplasm Metastasis - diagnostic imaging
Neoplasm Metastasis - physiopathology
Observational Study
Risk Factors
Sensitivity and Specificity
Thyroglobulin - analysis
Thyroglobulin - blood
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Summary:Nasopharyngeal carcinoma (NPC) has a distinctive geographical distribution in China, especially southern China. There are several risk factors for NPC, such as Epstein-Barr virus, genetics, and environmental exposures. Although the incidence of eye metastasis (EM) is lower than metastasis in other body parts, it often indicates poor prognosis.We assessed several serum biomarkers for their ability to predict EM in NPC. Patients with NPC were selected (n = 963), and were separated into two groups, EM and no eye metastasis. Ten factors were analyzed in both groups including triglyceride (TG), high-density lipoprotein, low-density lipoprotein, alkaline phosphatase, alpha fetoprotein, carbohydrate antigen-199, cancer antigen-153, apolipoproteins AI, apolipoprotein B, and cytokeratin fragment 19 (CYFRA21-1). Independent t tests, binary logistic regression, and receiver operating characteristic curves were used to assess the data.The EM group had significantly higher CYFRA21-1 and lower TG compared with the no eye metastasis group. Areas under the curve for CYFRA21-1, TG and CYFRA21-1/TG were 0.966, 0.771, and 0.976, respectively. The corresponding cut-off values were 12.12 ng/ml, 0.41 mmol/L, and 13.5. The sensitivity and specificity of CYFRA21-1/TG were 100% and 92.2%, respectively.The increased ratio of CYFRA21-1 to TG can be an accurate method to detect EM in patients with NPC.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000022773