Cortical midline structures associated with rumination in women with PTSD

Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral...

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Bibliographic Details
Published in:Journal of psychiatric research 2020-12, Vol.131, p.69-76
Main Authors: Philippi, Carissa L., Pessin, Sally, Reyna, Leah, Floyd, Tasheia, Bruce, Steven E.
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Brain Mapping
Cortical midline structures
Default mode network
Female
Humans
Isthmus cingulate
Magnetic Resonance Imaging
Parietal Lobe
Posttraumatic stress disorder
Precuneus
Rumination
Stress Disorders, Post-Traumatic - diagnostic imaging
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Summary:Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), and isthmus cingulate (IsthCing), in rumination in healthy and depressed populations. While past research has revealed dysfunction in cortical midline regions in PTSD, no studies have yet investigated the structural and functional neural mechanisms underlying rumination in women with PTSD. In the current study, we used structural MRI and resting-state fMRI to examine relationships between rumination and brain volume, as well as resting-state functional connectivity (rsFC) of cortical midline structures in women with PTSD due to interpersonal trauma (N = 71). We performed multiple linear regression analyses to relate brain volume in rACC, PCC, and IsthCing regions to self-reported rumination, after controlling for age and total intracranial volume. We also conducted standard seed-based voxelwise rsFC analyses for significant regions identified in the structural analysis. We found a significant relationship between greater rumination and volume in the left IsthCing (p = .025). Results from the rsFC analyses revealed a significant relationship between greater rumination and diminished rsFC between the left IsthCing and left precuneus (pFWE 
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2020.09.001