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Cortical midline structures associated with rumination in women with PTSD
Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral...
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| Published in: | Journal of psychiatric research 2020-12, Vol.131, p.69-76 |
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| creator | Philippi, Carissa L. Pessin, Sally Reyna, Leah Floyd, Tasheia Bruce, Steven E. |
| description | Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), and isthmus cingulate (IsthCing), in rumination in healthy and depressed populations. While past research has revealed dysfunction in cortical midline regions in PTSD, no studies have yet investigated the structural and functional neural mechanisms underlying rumination in women with PTSD. In the current study, we used structural MRI and resting-state fMRI to examine relationships between rumination and brain volume, as well as resting-state functional connectivity (rsFC) of cortical midline structures in women with PTSD due to interpersonal trauma (N = 71). We performed multiple linear regression analyses to relate brain volume in rACC, PCC, and IsthCing regions to self-reported rumination, after controlling for age and total intracranial volume. We also conducted standard seed-based voxelwise rsFC analyses for significant regions identified in the structural analysis. We found a significant relationship between greater rumination and volume in the left IsthCing (p = .025). Results from the rsFC analyses revealed a significant relationship between greater rumination and diminished rsFC between the left IsthCing and left precuneus (pFWE |
| doi_str_mv | 10.1016/j.jpsychires.2020.09.001 |
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•We investigated the neural correlates of ruminative thought in women with PTSD.•Greater PTSD symptom severity and symptom clusters were correlated with rumination.•Rumination was associated with increased gray matter volume in the IsthCing.•Rumination was also related to reduced connectivity between IsthCing and precuneus.•Findings suggest shared neural substrates of rumination in PTSD and depression.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2020.09.001</identifier><identifier>PMID: 32942190</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Brain - diagnostic imaging ; Brain Mapping ; Cortical midline structures ; Default mode network ; Female ; Humans ; Isthmus cingulate ; Magnetic Resonance Imaging ; Parietal Lobe ; Posttraumatic stress disorder ; Precuneus ; Rumination ; Stress Disorders, Post-Traumatic - diagnostic imaging</subject><ispartof>Journal of psychiatric research, 2020-12, Vol.131, p.69-76</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-78f6636a2f21160b13d5365012cdd2dea052e1f94167433c6bbf4c07e29871fd3</citedby><cites>FETCH-LOGICAL-c512t-78f6636a2f21160b13d5365012cdd2dea052e1f94167433c6bbf4c07e29871fd3</cites><orcidid>0000-0001-8672-2802</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32942190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Philippi, Carissa L.</creatorcontrib><creatorcontrib>Pessin, Sally</creatorcontrib><creatorcontrib>Reyna, Leah</creatorcontrib><creatorcontrib>Floyd, Tasheia</creatorcontrib><creatorcontrib>Bruce, Steven E.</creatorcontrib><title>Cortical midline structures associated with rumination in women with PTSD</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), and isthmus cingulate (IsthCing), in rumination in healthy and depressed populations. While past research has revealed dysfunction in cortical midline regions in PTSD, no studies have yet investigated the structural and functional neural mechanisms underlying rumination in women with PTSD. In the current study, we used structural MRI and resting-state fMRI to examine relationships between rumination and brain volume, as well as resting-state functional connectivity (rsFC) of cortical midline structures in women with PTSD due to interpersonal trauma (N = 71). We performed multiple linear regression analyses to relate brain volume in rACC, PCC, and IsthCing regions to self-reported rumination, after controlling for age and total intracranial volume. We also conducted standard seed-based voxelwise rsFC analyses for significant regions identified in the structural analysis. We found a significant relationship between greater rumination and volume in the left IsthCing (p = .025). Results from the rsFC analyses revealed a significant relationship between greater rumination and diminished rsFC between the left IsthCing and left precuneus (pFWE < .05). These findings provide novel support for alterations in the neural substrates of ruminative thought in women with PTSD. More broadly, we discuss clinical implications for targeted interventions to reduce rumination through psychotherapy or non-invasive brain stimulation.
•We investigated the neural correlates of ruminative thought in women with PTSD.•Greater PTSD symptom severity and symptom clusters were correlated with rumination.•Rumination was associated with increased gray matter volume in the IsthCing.•Rumination was also related to reduced connectivity between IsthCing and precuneus.•Findings suggest shared neural substrates of rumination in PTSD and depression.</description><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>Cortical midline structures</subject><subject>Default mode network</subject><subject>Female</subject><subject>Humans</subject><subject>Isthmus cingulate</subject><subject>Magnetic Resonance Imaging</subject><subject>Parietal Lobe</subject><subject>Posttraumatic stress disorder</subject><subject>Precuneus</subject><subject>Rumination</subject><subject>Stress Disorders, Post-Traumatic - diagnostic imaging</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvFDEQhC0EIpvAX0Bz5DKT9mPs9QUJllekSCARzpbX7mG9mrEX25Mo_55ZbQhw4tSHrv6qVUVIQ6GjQOXlvtsfyr3bhYylY8CgA90B0CdkRddKt5Qr_ZSsABhrue7lGTkvZQ8AilHxnJxxpgWjGlbkapNyDc6OzRT8GCI2pebZ1XkhN7aU5IKt6Ju7UHdNnqcQbQ0pNiE2d2nCeFp8vfn2_gV5Ntix4MuHeUG-f_xws_ncXn_5dLV5e926nrLaqvUgJZeWDYxSCVvKfc9lD5Q575lHCz1DOmhBpRKcO7ndDsKBQqbXig6eX5A3J-5h3k7oHcaa7WgOOUw235tkg_l3E8PO_Ei3Rkmpe0UXwOsHQE4_ZyzVTKE4HEcbMc3FMCEEV5KLo3R9krqcSsk4PNpQMMcmzN78acIcmzCgzdLEcvrq7zcfD39HvwjenQS4hHUbMJviAkaHfmG5anwK_3f5BU4poNk</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Philippi, Carissa L.</creator><creator>Pessin, Sally</creator><creator>Reyna, Leah</creator><creator>Floyd, Tasheia</creator><creator>Bruce, Steven E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8672-2802</orcidid></search><sort><creationdate>20201201</creationdate><title>Cortical midline structures associated with rumination in women with PTSD</title><author>Philippi, Carissa L. ; Pessin, Sally ; Reyna, Leah ; Floyd, Tasheia ; Bruce, Steven E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-78f6636a2f21160b13d5365012cdd2dea052e1f94167433c6bbf4c07e29871fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Brain - diagnostic imaging</topic><topic>Brain Mapping</topic><topic>Cortical midline structures</topic><topic>Default mode network</topic><topic>Female</topic><topic>Humans</topic><topic>Isthmus cingulate</topic><topic>Magnetic Resonance Imaging</topic><topic>Parietal Lobe</topic><topic>Posttraumatic stress disorder</topic><topic>Precuneus</topic><topic>Rumination</topic><topic>Stress Disorders, Post-Traumatic - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Philippi, Carissa L.</creatorcontrib><creatorcontrib>Pessin, Sally</creatorcontrib><creatorcontrib>Reyna, Leah</creatorcontrib><creatorcontrib>Floyd, Tasheia</creatorcontrib><creatorcontrib>Bruce, Steven E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philippi, Carissa L.</au><au>Pessin, Sally</au><au>Reyna, Leah</au><au>Floyd, Tasheia</au><au>Bruce, Steven E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical midline structures associated with rumination in women with PTSD</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>131</volume><spage>69</spage><epage>76</epage><pages>69-76</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Elevated rumination, characterized by repetitive, negative self-focused cognition, is common in posttraumatic stress disorder (PTSD) and has been shown to predict the onset and maintenance of the disorder. Neuroimaging research has implicated cortical midline brain structures, including the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), and isthmus cingulate (IsthCing), in rumination in healthy and depressed populations. While past research has revealed dysfunction in cortical midline regions in PTSD, no studies have yet investigated the structural and functional neural mechanisms underlying rumination in women with PTSD. In the current study, we used structural MRI and resting-state fMRI to examine relationships between rumination and brain volume, as well as resting-state functional connectivity (rsFC) of cortical midline structures in women with PTSD due to interpersonal trauma (N = 71). We performed multiple linear regression analyses to relate brain volume in rACC, PCC, and IsthCing regions to self-reported rumination, after controlling for age and total intracranial volume. We also conducted standard seed-based voxelwise rsFC analyses for significant regions identified in the structural analysis. We found a significant relationship between greater rumination and volume in the left IsthCing (p = .025). Results from the rsFC analyses revealed a significant relationship between greater rumination and diminished rsFC between the left IsthCing and left precuneus (pFWE < .05). These findings provide novel support for alterations in the neural substrates of ruminative thought in women with PTSD. More broadly, we discuss clinical implications for targeted interventions to reduce rumination through psychotherapy or non-invasive brain stimulation.
•We investigated the neural correlates of ruminative thought in women with PTSD.•Greater PTSD symptom severity and symptom clusters were correlated with rumination.•Rumination was associated with increased gray matter volume in the IsthCing.•Rumination was also related to reduced connectivity between IsthCing and precuneus.•Findings suggest shared neural substrates of rumination in PTSD and depression.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32942190</pmid><doi>10.1016/j.jpsychires.2020.09.001</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8672-2802</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Brain - diagnostic imaging Brain Mapping Cortical midline structures Default mode network Female Humans Isthmus cingulate Magnetic Resonance Imaging Parietal Lobe Posttraumatic stress disorder Precuneus Rumination Stress Disorders, Post-Traumatic - diagnostic imaging |
| title | Cortical midline structures associated with rumination in women with PTSD |
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