Radioactive Seed Versus Wire-Guided Localization for Ductal Carcinoma in Situ of the Breast: Comparable Resection Margins

Background There are currently two widely used methods for preoperative localization of ductal carcinoma in situ (DCIS) of the breast: wire-guided localization (WGL) and radioactive seed localization (RSL). Several studies compared these localization techniques in small cohorts. Objective The aim of...

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Bibliographic Details
Published in:Annals of surgical oncology 2020-12, Vol.27 (13), p.5296-5302
Main Authors: Agahozo, Marie Colombe, Berghuis, Sofie A.M., van den Broek, Esther, Koppert, Linetta B., Obdeijn, Inge-Marie, van Deurzen, Carolien H. M.
Format: Article
Language:English
Subjects:
Breast
Breast cancer
Breast Neoplasms - surgery
Breast Oncology
Carcinoma, Ductal, Breast - diagnostic imaging
Carcinoma, Ductal, Breast - surgery
Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating - surgery
Cohort Studies
Humans
Iodine Radioisotopes
Localization
Margins of Excision
Mastectomy
Mastectomy, Segmental
Medicine
Medicine & Public Health
Oncology
Retrospective Studies
Surgery
Surgical Oncology
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Summary:Background There are currently two widely used methods for preoperative localization of ductal carcinoma in situ (DCIS) of the breast: wire-guided localization (WGL) and radioactive seed localization (RSL). Several studies compared these localization techniques in small cohorts. Objective The aim of this study was to compare the surgical resection margin status between RSL and WGL in a large national cohort of patients with DCIS. Patients and Methods We included patients from the Dutch Pathology Registry who underwent breast-conserving surgery for DCIS by either RSL ( n  = 1851) or WGL ( n  = 2187) between 2009 and 2019. Several clinicopathological characteristics were compared between these two groups, including resection margin status and number of re-excisions. Results Patients undergoing RSL were younger ( p  = 0.014) and were more often diagnosed with a large DCIS ( p  = 0.013), high grade DCIS ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08744-8