Exosomes and breast cancer drug resistance

Drug resistance is a daunting challenge in the treatment of breast cancer (BC). Exosomes, as intercellular communicative vectors in the tumor microenvironment, play an important role in BC progression. With the in-depth understanding of tumor heterogeneity, an emerging role of exosomes in drug resis...

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Bibliographic Details
Published in:Cell death & disease 2020-11, Vol.11 (11), p.987-987, Article 987
Main Authors: Dong, Xingli, Bai, Xupeng, Ni, Jie, Zhang, Hao, Duan, Wei, Graham, Peter, Li, Yong
Format: Article
Language:English
Subjects:
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Antibodies
Biochemistry
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Cell Biology
Cell Culture
Drug metabolism
Drug resistance
Drug Resistance, Neoplasm
Exosomes
Exosomes - metabolism
Female
Humans
Immunology
Life Sciences
Mesenchyme
Non-coding RNA
Review
Review Article
Stromal cells
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Summary:Drug resistance is a daunting challenge in the treatment of breast cancer (BC). Exosomes, as intercellular communicative vectors in the tumor microenvironment, play an important role in BC progression. With the in-depth understanding of tumor heterogeneity, an emerging role of exosomes in drug resistance has attracted extensive attention. The functional proteins or non-coding RNAs contained in exosomes secreted from tumor and stromal cells mediate drug resistance by regulating drug efflux and metabolism, pro-survival signaling, epithelial–mesenchymal transition, stem-like property, and tumor microenvironmental remodeling. In this review, we summarize the underlying associations between exosomes and drug resistance of BC and discuss the unique biogenesis of exosomes, the change of exosome cargo, and the pattern of release by BC cells in response to drug treatment. Moreover, we propose exosome as a candidate biomarker in predicting and monitoring the therapeutic drug response of BC and as a potential target or carrier to reverse the drug resistance of BC.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-020-03189-z