Etiology, baseline clinical profile and comorbidities of patients with Cushing’s syndrome at a single endocrinological center

Purpose The aim of this study was to compare phenotype of patients with pituitary, adrenal and ectopic CS and identify the differences regarding biochemical parameters, clinical presentations, and comorbidities in CS patients who were diagnosed at the single endocrinological center in Wroclaw. Metho...

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Bibliographic Details
Published in:Endocrine 2020-12, Vol.70 (3), p.616-628
Main Authors: Stachowska, Barbara, Kuliczkowska-Płaksej, Justyna, Kałużny, Marcin, Grzegrzółka, Jędrzej, Jończyk, Maja, Bolanowski, Marek
Format: Article
Language:English
Subjects:
Cushing Syndrome - complications
Cushing Syndrome - epidemiology
Diabetes
Endocrinology
Female
Humanities and Social Sciences
Humans
Hydrocortisone
Hypertension - epidemiology
Hypokalemia
Internal Medicine
Male
Medicine
Medicine & Public Health
multidisciplinary
Original
Original Article
Pituitary Diseases
Science
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Summary:Purpose The aim of this study was to compare phenotype of patients with pituitary, adrenal and ectopic CS and identify the differences regarding biochemical parameters, clinical presentations, and comorbidities in CS patients who were diagnosed at the single endocrinological center in Wroclaw. Methods The study population involved 64 patients with CS (53 women and 11 men) diagnosed in Department of Endocrinology, Diabetes and Isotope Therapy in 2000–2018. Patients were divided into three etiologic groups: pituitary dependent-CS (P-CS) (64%), adrenal dependent CS (A-CS) (25%), and CS from an ectopic source (E-CS) (11%). Results Percentage of men in the A-CS group was significantly higher than in the other etiologic groups. ACTH, UFC, and cortisol in DST were significantly higher in E-CS group compare to P-CS and A-CS ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02468-1